Process for preparation of MR contrast agents

Oskar Axelsson, Charlotte Olofsson, Axel Morgenstjerne, Georg Hansson, Haukur Johannesson, Jan Henrik Ardenkjær-Larsen

Research output: Contribution to journalJournal articleResearch

Abstract

The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H-2) enriched in para-hydrogen (p-H-1(2)) and/or ortho-deuterium (o-H-2(2)) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
Original languageEnglish
JournalU.S. Patent and Trademark Office. Official Gazette. Patents
ISSN0098-1133
Publication statusPublished - 2008
Externally publishedYes

Fingerprint Dive into the research topics of 'Process for preparation of MR contrast agents'. Together they form a unique fingerprint.

Cite this