Process for preparation of MR contrast agents

Oskar Axelsson (Inventor), Charlotte Olofsson (Inventor), Axel Morgenstjerne (Inventor), Georg Hansson (Inventor), Haukur Johannesson (Inventor), Jan Henrik Ardenkjær-Larsen (Inventor)

    Research output: Patent

    145 Downloads (Pure)

    Abstract

    The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.

    Original languageEnglish
    IPCG01R 33/ 483 A N
    Patent numberUS2002137965
    Filing date26/09/2002
    Country/TerritoryUnited States
    Priority date16/11/2001
    Priority numberUS20010990537
    Publication statusPublished - 26 Sept 2002

    Bibliographical note

    Also published as: US6872380 (B2) WO0071166 (A2) WO0071166 (A3) US2005152840 (A1) US7459144 (B2)

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