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A major challenge in the transaminase catalysed synthesis of chiral amines is the unfavourable equilibrium position . There are several solutions to such equilibrium problems, including the use of in-situ product removal (ISPR) and cascade reactions to degrade or recycle the co-product formed. Such techniques, especially those using cascades can be a great tool to overcome the thermodynamic hurdle, but also present some new challenges with respect to compatibility of reaction conditions, recycling of co-factors and last but not least, the added cost of the cascade system components .
In this lecture we will present several process engineering tools including the use of mathematical modelling, uncertainty and sensitivity analysis  as well as economic evaluation and defined experimental protocols to help evaluate the feasibility of new biocatalytic cascades. The concepts will be illustrated with data from transaminase catalysed syntheses we have been modelling and studying experimentally at DTU.
|Publication status||Published - 2012|
|Event||Multistep Enzyme-Catalyzed Processes 2012 - University of Graz, Graz, Austria|
Duration: 10 Apr 2012 → 13 Apr 2012
|Conference||Multistep Enzyme-Catalyzed Processes 2012|
|Location||University of Graz|
|Period||10/04/2012 → 13/04/2012|
Bibliographical noteOral presentation.
The authors acknowledge the support of project AMBIOCAS, financed through the European Union 7th Framework Programme (Grant agreement no.: 245144)
 P. Tufvesson, J. Lima-Ramos, J. J. Skibsted, N. Al-Haque, W. Neto, J. M. Woodley, Biotech. Bioeng. 2011, 108, 1479-1493
 P. Tufvesson, J. Lima-Ramos, M. Nordblad, J. M. Woodley, Org Process Res Dev, 2011, 15, 266-274
 P. G. Andrade Santacoloma, G. Sin, K. V. Gernaey, J. M. Woodley, Org Process Res Dev, 2011, 15, 203-212
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- 1 Conference presentations
Pär Tufvesson (Speaker)13 Apr 2012
Activity: Talks and presentations › Conference presentationsFile