Process design implications of aldehyde properties on transketolase-catalysed condensations

R. K. Mitra, John Woodley, M. D. Lilly

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Recently we have devised a systematic approach to selection and operation of biotransformation reactions. Such an approach is based on reaction characterisation leading to the identification of constraints and subsequent process synthesis. In this paper we illustrate how this approach can be applied to a model system (condensation of glycolaldehyde with beta-hydroxypyruvate by transketolase to synthesise L-erythrulose) as the basis for rapidly evaluating a second system with different aldehyde properties (condensation of racemic 3-oxy-benzylglyceraldehyde with beta-hydroxypyruvate to synthesise (3S,4R)-5-oxy-benzyl-D-xylulose). Some general conclusions are drawn.
Original languageEnglish
JournalBiocatalysis and Biotransformation
Volume17
Issue number1
Pages (from-to)21-36
ISSN1024-2422
DOIs
Publication statusPublished - 1999
Externally publishedYes

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