Process considerations for use of galactose oxidase as an industrial biocatalyst

Asbjørn Toftgaard Pedersen, Gustav Rehn, John M. Woodley

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In nature galactose oxidase (GOase, EC. catalyses the oxidation of the C6 hydroxyl group of D-galactose to the corresponding aldehyde, while reducing molecular oxygen to hydrogen peroxide. In recent years a great effort has been made to broaden the substrate scope, enabling GOase to oxidize C6-OH of glucose and fructose, as well as secondary alcohols to ketones. The widened substrate scope of GOase opens up many important industrial applications, such as synthesis of industrially relevant compounds containing aldehydes and ketones (e.g. the oxidation of 5-hydroxymethylfurfural to diformylfuran), deracemization of secondary alcohols, and modification of a wide range of naturally occurring polysaccharides [1,2]. Despite these promising characteristics of GOase, application at industrial scale has not been achieved so far. This can in part be ascribed to the process challenges experienced when performing oxidative biocatalysis at a large scale
Original languageEnglish
Publication date2015
Number of pages1
Publication statusPublished - 2015
EventEnzyme Engineering XXIII - St. Petersburg, United States
Duration: 6 Sept 201510 Sept 2015


ConferenceEnzyme Engineering XXIII
Country/TerritoryUnited States
CitySt. Petersburg


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