Probiotic Escherichia coli strain Nissle 1917 outcompetes intestinal pathogens during biofilm formation

Viktoria Hancock, M. Dahl, Per Klemm

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Many bacterial infections are associated with biofilm formation. Bacterial biofilms can develop on essentially all kinds of surfaces, producing chronic and often intractable infections. Escherichia coil is an important pathogen causing a wide range of gastrointestinal infections. E. coli strain Nissle 1917 has been used for many decades as a probiotic against a variety of intestinal disorders and is probably the best field-tested E. coil strain in the world. Here we have investigated the biofilm-forming capacity of Nissle 1917. We found that the strain was a good biofilm former. Not only was it significantly better at biofilm formation than enteropathogenic, enterotoxigenic and enterohaemorrhagic E. cull strains, it was also able to outcompete such strains during biofilm formation. The results support the notion of bacterial prophylaxis employing Nissle 1917 and may partially explain why the strain has a beneficial effect on many intestinal disorders.
    Original languageEnglish
    JournalJournal of Medical Microbiology
    Volume59
    Issue number4
    Pages (from-to)392-399
    ISSN0022-2615
    DOIs
    Publication statusPublished - 2010

    Fingerprint Dive into the research topics of 'Probiotic Escherichia coli strain Nissle 1917 outcompetes intestinal pathogens during biofilm formation'. Together they form a unique fingerprint.

    Cite this