Probing the aglycon binding site of a b-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors

Tanja Wrodnigg, Frederik Diness, Christoph Gruber, Herwig Häusler, Inge Lundt, Karen Rupitz, Andreas Steiner, Arnold E. Stütz, Chris A. Tarling, Stephen G. Withers, Heidrun Wölfler

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the b-glucosidase from Agrobacterium sp. Ki values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/inhibitor binding.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry
Volume12
Issue number13
Pages (from-to)3485-3495
ISSN0968-0896
DOIs
Publication statusPublished - 2004

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