Abstract
A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has
been synthesised and their biological activities probed with the b-glucosidase from Agrobacterium sp. Ki values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/inhibitor binding.
Original language | English |
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Journal | Bioorganic & Medicinal Chemistry |
Volume | 12 |
Issue number | 13 |
Pages (from-to) | 3485-3495 |
ISSN | 0968-0896 |
DOIs | |
Publication status | Published - 2004 |