Probabilistic cumulative risk assessment of anti-androgenic pesticides in food

Anne Kirstine Müller, Elsa Nielsen

Research output: Contribution to journalConference abstract in journalResearch

Abstract

A cumulative risk assessment of three anti-androgenic pesticides vinclozolin, procymidone and prochloraz in combination has been carried out using an Integrated Probabilistic Risk Assessment (IPRA) model. In the model, variability in both exposure and sensitivity between individuals were combined into a distribution of Individual Margins of Exposure (IMoE). Additionally, uncertainties related to input parameters were evaluated. The cumulative risk assessment was performed using the Relative Potency Factor (RPF) approach. RPFs for each substance were estimated for three reproductive endpoints in male foetuses as observed following in utero exposure in rats (ano-genital distance, and weight of the seminal vesicles and the levator ani/bulbocavernosus (LABC) muscles). The estimations of the cumulative dietary intake were based on consumption data (1997–1998) and residue data (2002–2003) from the Netherlands.

Inter- and intraspecies extrapolation factors were included in the assessment and IMoEs of 1 or less indicate a possible concern. The assessment did not result in IMoEs equal to or less than 1. The endpoint ‘weight of the seminal vesicles’ resulted in the lowest IMoEs (0.1th percentile: 198; 90% CI: 23.5–423) and the fraction of individuals with an IMoE of less than 1000 was 1.43% (90%CI: 0.33–4.85). For the two other endpoints, the fractions were slightly lower. This implies that cumulative exposure of Dutch women to vinclozolin, procymidone and prochloraz in combination is not likely to be of concern for the reproductive development of male foetuses following prenatal exposure. However, other anti-androgenic substances should be included in the cumulative assessment to make it more comprehensive.
Original languageEnglish
JournalToxicology Letters
Volume180
Issue numberS
Pages (from-to)S72-S72
ISSN0378-4274
DOIs
Publication statusPublished - 2008
Event45th Congress of The European Societies of Toxicology - Rhodes, Greece
Duration: 5 Oct 20088 Oct 2008
Conference number: 45

Conference

Conference45th Congress of The European Societies of Toxicology
Number45
CountryGreece
CityRhodes
Period05/10/200808/10/2008

Cite this

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title = "Probabilistic cumulative risk assessment of anti-androgenic pesticides in food",
abstract = "A cumulative risk assessment of three anti-androgenic pesticides vinclozolin, procymidone and prochloraz in combination has been carried out using an Integrated Probabilistic Risk Assessment (IPRA) model. In the model, variability in both exposure and sensitivity between individuals were combined into a distribution of Individual Margins of Exposure (IMoE). Additionally, uncertainties related to input parameters were evaluated. The cumulative risk assessment was performed using the Relative Potency Factor (RPF) approach. RPFs for each substance were estimated for three reproductive endpoints in male foetuses as observed following in utero exposure in rats (ano-genital distance, and weight of the seminal vesicles and the levator ani/bulbocavernosus (LABC) muscles). The estimations of the cumulative dietary intake were based on consumption data (1997–1998) and residue data (2002–2003) from the Netherlands.Inter- and intraspecies extrapolation factors were included in the assessment and IMoEs of 1 or less indicate a possible concern. The assessment did not result in IMoEs equal to or less than 1. The endpoint ‘weight of the seminal vesicles’ resulted in the lowest IMoEs (0.1th percentile: 198; 90{\%} CI: 23.5–423) and the fraction of individuals with an IMoE of less than 1000 was 1.43{\%} (90{\%}CI: 0.33–4.85). For the two other endpoints, the fractions were slightly lower. This implies that cumulative exposure of Dutch women to vinclozolin, procymidone and prochloraz in combination is not likely to be of concern for the reproductive development of male foetuses following prenatal exposure. However, other anti-androgenic substances should be included in the cumulative assessment to make it more comprehensive.",
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Probabilistic cumulative risk assessment of anti-androgenic pesticides in food. / Müller, Anne Kirstine; Nielsen, Elsa.

In: Toxicology Letters, Vol. 180, No. S, 2008, p. S72-S72.

Research output: Contribution to journalConference abstract in journalResearch

TY - ABST

T1 - Probabilistic cumulative risk assessment of anti-androgenic pesticides in food

AU - Müller, Anne Kirstine

AU - Nielsen, Elsa

PY - 2008

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N2 - A cumulative risk assessment of three anti-androgenic pesticides vinclozolin, procymidone and prochloraz in combination has been carried out using an Integrated Probabilistic Risk Assessment (IPRA) model. In the model, variability in both exposure and sensitivity between individuals were combined into a distribution of Individual Margins of Exposure (IMoE). Additionally, uncertainties related to input parameters were evaluated. The cumulative risk assessment was performed using the Relative Potency Factor (RPF) approach. RPFs for each substance were estimated for three reproductive endpoints in male foetuses as observed following in utero exposure in rats (ano-genital distance, and weight of the seminal vesicles and the levator ani/bulbocavernosus (LABC) muscles). The estimations of the cumulative dietary intake were based on consumption data (1997–1998) and residue data (2002–2003) from the Netherlands.Inter- and intraspecies extrapolation factors were included in the assessment and IMoEs of 1 or less indicate a possible concern. The assessment did not result in IMoEs equal to or less than 1. The endpoint ‘weight of the seminal vesicles’ resulted in the lowest IMoEs (0.1th percentile: 198; 90% CI: 23.5–423) and the fraction of individuals with an IMoE of less than 1000 was 1.43% (90%CI: 0.33–4.85). For the two other endpoints, the fractions were slightly lower. This implies that cumulative exposure of Dutch women to vinclozolin, procymidone and prochloraz in combination is not likely to be of concern for the reproductive development of male foetuses following prenatal exposure. However, other anti-androgenic substances should be included in the cumulative assessment to make it more comprehensive.

AB - A cumulative risk assessment of three anti-androgenic pesticides vinclozolin, procymidone and prochloraz in combination has been carried out using an Integrated Probabilistic Risk Assessment (IPRA) model. In the model, variability in both exposure and sensitivity between individuals were combined into a distribution of Individual Margins of Exposure (IMoE). Additionally, uncertainties related to input parameters were evaluated. The cumulative risk assessment was performed using the Relative Potency Factor (RPF) approach. RPFs for each substance were estimated for three reproductive endpoints in male foetuses as observed following in utero exposure in rats (ano-genital distance, and weight of the seminal vesicles and the levator ani/bulbocavernosus (LABC) muscles). The estimations of the cumulative dietary intake were based on consumption data (1997–1998) and residue data (2002–2003) from the Netherlands.Inter- and intraspecies extrapolation factors were included in the assessment and IMoEs of 1 or less indicate a possible concern. The assessment did not result in IMoEs equal to or less than 1. The endpoint ‘weight of the seminal vesicles’ resulted in the lowest IMoEs (0.1th percentile: 198; 90% CI: 23.5–423) and the fraction of individuals with an IMoE of less than 1000 was 1.43% (90%CI: 0.33–4.85). For the two other endpoints, the fractions were slightly lower. This implies that cumulative exposure of Dutch women to vinclozolin, procymidone and prochloraz in combination is not likely to be of concern for the reproductive development of male foetuses following prenatal exposure. However, other anti-androgenic substances should be included in the cumulative assessment to make it more comprehensive.

U2 - 10.1016/j.toxlet.2008.06.580

DO - 10.1016/j.toxlet.2008.06.580

M3 - Conference abstract in journal

VL - 180

SP - S72-S72

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - S

ER -