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Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis. / Hjorth, Mads F.; Blædel, Trine; Bendtsen, Line Q.; Lorenzen, Janne K.; Holm, Jacob B.; Kiilerich, Pia; Roager, Henrik Munch; Kristiansen, Karsten; Larsen, Lesli H.; Astrup, Arne.

In: International Journal of Obesity, Vol. 43, 2019, p. 149-157.

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Hjorth, Mads F. ; Blædel, Trine ; Bendtsen, Line Q. ; Lorenzen, Janne K. ; Holm, Jacob B. ; Kiilerich, Pia ; Roager, Henrik Munch ; Kristiansen, Karsten ; Larsen, Lesli H. ; Astrup, Arne. / Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis. In: International Journal of Obesity. 2019 ; Vol. 43. pp. 149-157.

Bibtex

@article{c7c2ba21777d480698c21df48a406c15,
title = "Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis",
abstract = "Background/objectives: Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B. Subjects/methods: Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E{\%}) fat, 52 E{\%} carbohydrate and 18 E{\%} protein either high ({\^a}‰ˆ1500 mg calcium/day) or low ( {\^a}‰¤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models. Results: Independent of the randomized diets, individuals with high P/B lost 3.8 kg (95{\%}CI, 1.8,5.8; P <0.001) more body weight and 3.8 kg (95{\%} CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (95{\%} CI, 5.8;10.9, P <0.001) more body weight when consuming above compared to below 30 g fiber/10MJ whereas this weight loss was 3.2 kg (95{\%} CI, 0.8;5.5, P = 0.008) among individuals with low P/B ratio [Mean difference: 5.1 kg (95{\%} CI, 1.7;8.6, P = 0.003)]. Partial correlation coefficients between fiber intake and weight change was 0.90 (P <0.001) among individuals with high P/B ratio and 0.25 (P = 0.29) among individuals with low P/B ratio. Conclusions: Individuals with high P/B lost more body weight and body fat compared to individuals with low P/B, confirming that individuals with a high P/B are more susceptible to weight loss on a diet rich in fiber.",
author = "Hjorth, {Mads F.} and Trine Bl{\ae}del and Bendtsen, {Line Q.} and Lorenzen, {Janne K.} and Holm, {Jacob B.} and Pia Kiilerich and Roager, {Henrik Munch} and Karsten Kristiansen and Larsen, {Lesli H.} and Arne Astrup",
year = "2019",
doi = "10.1038/s41366-018-0093-2",
language = "English",
volume = "43",
pages = "149--157",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis

AU - Hjorth, Mads F.

AU - Blædel, Trine

AU - Bendtsen, Line Q.

AU - Lorenzen, Janne K.

AU - Holm, Jacob B.

AU - Kiilerich, Pia

AU - Roager, Henrik Munch

AU - Kristiansen, Karsten

AU - Larsen, Lesli H.

AU - Astrup, Arne

PY - 2019

Y1 - 2019

N2 - Background/objectives: Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B. Subjects/methods: Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E%) fat, 52 E% carbohydrate and 18 E% protein either high (≈1500 mg calcium/day) or low ( ≤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models. Results: Independent of the randomized diets, individuals with high P/B lost 3.8 kg (95%CI, 1.8,5.8; P <0.001) more body weight and 3.8 kg (95% CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (95% CI, 5.8;10.9, P <0.001) more body weight when consuming above compared to below 30 g fiber/10MJ whereas this weight loss was 3.2 kg (95% CI, 0.8;5.5, P = 0.008) among individuals with low P/B ratio [Mean difference: 5.1 kg (95% CI, 1.7;8.6, P = 0.003)]. Partial correlation coefficients between fiber intake and weight change was 0.90 (P <0.001) among individuals with high P/B ratio and 0.25 (P = 0.29) among individuals with low P/B ratio. Conclusions: Individuals with high P/B lost more body weight and body fat compared to individuals with low P/B, confirming that individuals with a high P/B are more susceptible to weight loss on a diet rich in fiber.

AB - Background/objectives: Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B. Subjects/methods: Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E%) fat, 52 E% carbohydrate and 18 E% protein either high (≈1500 mg calcium/day) or low ( ≤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models. Results: Independent of the randomized diets, individuals with high P/B lost 3.8 kg (95%CI, 1.8,5.8; P <0.001) more body weight and 3.8 kg (95% CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (95% CI, 5.8;10.9, P <0.001) more body weight when consuming above compared to below 30 g fiber/10MJ whereas this weight loss was 3.2 kg (95% CI, 0.8;5.5, P = 0.008) among individuals with low P/B ratio [Mean difference: 5.1 kg (95% CI, 1.7;8.6, P = 0.003)]. Partial correlation coefficients between fiber intake and weight change was 0.90 (P <0.001) among individuals with high P/B ratio and 0.25 (P = 0.29) among individuals with low P/B ratio. Conclusions: Individuals with high P/B lost more body weight and body fat compared to individuals with low P/B, confirming that individuals with a high P/B are more susceptible to weight loss on a diet rich in fiber.

U2 - 10.1038/s41366-018-0093-2

DO - 10.1038/s41366-018-0093-2

M3 - Journal article

VL - 43

SP - 149

EP - 157

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -