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  • Author: Hjorth, Mads F.

    University of Copenhagen, Denmark

  • Author: Blædel, Trine

    University of Copenhagen, Denmark

  • Author: Bendtsen, Line Q.

    University of Copenhagen, Denmark

  • Author: Lorenzen, Janne Kunchel

    University of Copenhagen, Denmark

  • Author: Holm, Jacob Bak

    University of Copenhagen, Denmark

  • Author: Kiilerich, Pia

    University of Copenhagen, Denmark

  • Author: Roager, Henrik Munch

    Research Group for Gut Microbiology and Immunology, National Food Institute, Technical University of Denmark, Kemitorvet, 2800, Lyngby, Denmark

  • Author: Kristiansen, Karsten

    University of Copenhagen, Denmark

  • Author: Larsen, Lesli Hingstrup

    University of Copenhagen, Denmark

  • Author: Astrup, Arne

    University of Copenhagen, Denmark

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Background/objectives: Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B. Subjects/methods: Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E%) fat, 52 E% carbohydrate and 18 E% protein either high (≈1500 mg calcium/day) or low ( ≤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models. Results: Independent of the randomized diets, individuals with high P/B lost 3.8 kg (95%CI, 1.8,5.8; P <0.001) more body weight and 3.8 kg (95% CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (95% CI, 5.8;10.9, P <0.001) more body weight when consuming above compared to below 30 g fiber/10MJ whereas this weight loss was 3.2 kg (95% CI, 0.8;5.5, P = 0.008) among individuals with low P/B ratio [Mean difference: 5.1 kg (95% CI, 1.7;8.6, P = 0.003)]. Partial correlation coefficients between fiber intake and weight change was 0.90 (P <0.001) among individuals with high P/B ratio and 0.25 (P = 0.29) among individuals with low P/B ratio. Conclusions: Individuals with high P/B lost more body weight and body fat compared to individuals with low P/B, confirming that individuals with a high P/B are more susceptible to weight loss on a diet rich in fiber.
Original languageEnglish
JournalInternational Journal of Obesity
Volume43
Pages (from-to)149-157
ISSN0307-0565
DOIs
Publication statusPublished - 2019
CitationsWeb of Science® Times Cited: No match on DOI

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