Prevention of bacterial adhesion

Per Klemm, Rebecca Munk Vejborg, Viktoria Hancock

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Management of bacterial infections is becoming increasingly difficult due to the emergence and increasing prevalence of bacterial pathogens that are resistant to available antibiotics. Conventional antibiotics generally kill bacteria by interfering with vital cellular functions, an approach that imposes selection pressure for resistant bacteria. New approaches are urgently needed. Targeting bacterial virulence functions directly is an attractive alternative. An obvious target is bacterial adhesion. Bacterial adhesion to surfaces is the first step in colonization, invasion, and biofilm formation. As such, adhesion represents the Achilles heel of crucial pathogenic functions. It follows that interference with adhesion can reduce bacterial virulence. Here, we illustrate this important topic with examples of techniques being developed that can inhibit bacterial adhesion. Some of these will become valuable weapons for preventing pathogen contamination and fighting infectious diseases in the future.
Original languageEnglish
JournalApplied Microbiology and Biotechnology
Volume88
Issue number2
Pages (from-to)451-459
ISSN0175-7598
Publication statusPublished - 2010

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