Pressure-Driven DNA in Nanogroove Arrays: Complex Dynamics Leads to Length- and Topology-Dependent Separation

Morten Bo Lindholm Mikkelsen; Walter Reisner; Henrik Flyvbjerg; Anders Kristensen

doi:10.1021/nl1044764

Pressure-Driven DNA in Nanogroove Arrays: Complex Dynamics Leads to Length- and Topology-Dependent Separation

Morten Bo Lindholm Mikkelsen, Walter Reisner, Henrik Flyvbjerg, Anders Kristensen

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Abstract

The motion of linear and circular DNA molecules is studied under pressure driven buffer flow in a 50 nm slit channel with arrays of transverse 150 nm deep nanogrooves. Transport occurs through two states of propagation unique to this nanogroove geometry, a slow, stepwise groove-to-groove translation called the “sidewinder” and a fast, continuous tumbling across the grooves called the “tumbleweed”. Dynamical transitions between the two states are observed at fixed buffer velocity. Molecules exhibit size- and topology-dependent velocities.

Original language	English
Journal	Nano Letters
Volume	11
Issue number	4
Pages (from-to)	1598–1602
ISSN	1530-6984
DOIs	https://doi.org/10.1021/nl1044764
Publication status	Published - 2011

Bibliographical note

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/nl1044764

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title = "Pressure-Driven DNA in Nanogroove Arrays: Complex Dynamics Leads to Length- and Topology-Dependent Separation",

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AU - Kristensen, Anders

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/nl1044764

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Pressure-Driven DNA in Nanogroove Arrays: Complex Dynamics Leads to Length- and Topology-Dependent Separation

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