Preparing an alkaline earth metal or another divalent metal ion salt of organic acid for e.g. medicine comprises reacting a hydroxide or halogen salt of a metal ion with organic acid in aqueous medium

Stephan Christgau (Inventor), Jens Enevold Thaulov Andersen (Inventor), J. Andersen (Inventor), S./A.J. Christgau (Inventor)

Research output: Patent

Abstract

Preparing (M1) an alkaline earth metal and/or another divalent metal ion salt of an organic acid comprises reacting at least one of a hydroxide and/or a halogen salt of the metal ion with the organic acid (anion) in an aqueous medium at greater than or equal to90 (e.g. greater than or equal to100, greater than or equal to120, or greater than or equal to125)degreesC for at the most 60 (e.g. at the most 30 or at the most 20 or about 15) minutes. USE - In preparation of an alkaline earth metal and/or another divalent metal ion salts of an organic acid e.g. strontium salt useful in medicine (claimed), and industrial processes; in the production of food products, pharmaceuticals ingredients, vitamins, and other health related products; in products for personal care e.g. creams, lotions, and toothpastes; and industrial products such as fertilizers, building materials, glass, ion and steel manufacture. The strontium salts of dicarboxylic organic anions are useful in the treatment of metabolic bone disease. ADVANTAGE - The method provides the divalent metal salt in greater than or equal to70 (preferably greater than or equal to75, greater than or equal to80, greater than or equal to85, greater than or equal to90 or greater than or equal to95)% yield. The method provides metal-ion salts with high purity, controlled homogeneity and improved yield. The method enables use of much higher reaction temperature than room temperature; and provides the divalent salt in higher yield while keeping the formation of carbonate at very low limit i.e. amount of precipitated carbonate is less than 1 (preferably less than 0.5 or less than 0.2)% of the amount of divalent metal salt. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for new strontium salts i.e. strontium (L-) diglutamate pentahydrate; and strontium D-glutamate hexahydrate.
Original languageEnglish
Patent numberWO2005108339-A2; EP1744770-A2; AU2005240257-A1; KR2007031312-A; US2007282127-A1; JP2007536288-W; CN101010087-A; US7589235-B2
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Publication statusPublished - 2005
Externally publishedYes

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