Abstract
A method for the synthesis of dendrimer conjugates having a well-defined chemical structure, comprising one or more carbohydrate moieties and one or more immunomodulating substances coupled to a dendrimer, is presented. First, the carbohydrate is bound to the dendrimer in a chemoselective manner. Subsequently, the immunomodulating substance is also bound in a chemoselective manner, to give a dendrimer conjugate with a well-defined structure and connectivity and containing a precise, pre-determined ratio of carbohydrate to immunomodulating substance. The invention also relates to novel dendrimer conjugates and their use in vaccination, production of antibodies, high throughput screening, diagnostic assays and libraries.
| Original language | English |
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| Patent number | WO2004041310 |
| Filing date | 21/05/2004 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Publication status | Published - 2004 |
