PREPARATION OF CHEMICALLY WELL-DEFINED CARBOHYDRATE DENDRIMER CONJUGATES

Peter M. H. Heegaard (Inventor), Ulrik Boas (Inventor)

    Research output: Patent

    Abstract

    A method for the synthesis of dendrimer conjugates having a well-defined chemical structure, comprising one or more carbohydrate moieties and one or more immunomodulating substances coupled to a dendrimer, is presented. First, the carbohydrate is bound to the dendrimer in a chemoselective manner. Subsequently, the immunomodulating substance is also bound in a chemoselective manner, to give a dendrimer conjugate with a well-defined structure and connectivity and containing a precise, pre-determined ratio of carbohydrate to immunomodulating substance. The invention also relates to novel dendrimer conjugates and their use in vaccination, production of antibodies, high throughput screening, diagnostic assays and libraries.
    Original languageEnglish
    Patent numberWO2004041310
    Filing date21/05/2004
    CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
    Publication statusPublished - 2004

    Bibliographical note

    International application published under the World Intellectual Property Organization (WIPO)

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