Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

Line Hagner Nielsen; Sarah Gordon; René  Holm; Arzu Selen; T. Rades; A. Müllertz

doi:10.1016/j.ejpb.2013.09.002

Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

Line Hagner Nielsen
, Sarah Gordon
, René Holm
, Arzu Selen
, T. Rades
, A. Müllertz

Research output: Contribution to journal › Journal article › Research › peer-review

Original language	English
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	85
Issue number	3
Pages (from-to)	942-951
ISSN	0939-6411
DOIs	https://doi.org/10.1016/j.ejpb.2013.09.002
Publication status	Published - 2013
Externally published	Yes

Keywords

Poorly soluble drugs
Amorphous salt
Furosemide
Biorelevant dissolution
Solubility
Oral bioavailability

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10.1016/j.ejpb.2013.09.002

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Cite this

@article{6ed253a54987431cb8974aa634e6037a,

title = "Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats",

keywords = "Poorly soluble drugs, Amorphous salt, Furosemide, Biorelevant dissolution, Solubility, Oral bioavailability",

author = "Nielsen, \{Line Hagner\} and Sarah Gordon and Ren{\'e} Holm and Arzu Selen and T. Rades and A. M{\"u}llertz",

year = "2013",

doi = "10.1016/j.ejpb.2013.09.002",

language = "English",

volume = "85",

pages = "942--951",

journal = "European Journal of Pharmaceutics and Biopharmaceutics",

issn = "0939-6411",

publisher = "Elsevier",

number = "3",

}

Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats. / Nielsen, Line Hagner; Gordon, Sarah; Holm, René et al.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 85, No. 3, 2013, p. 942-951.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

AU - Nielsen, Line Hagner

AU - Gordon, Sarah

AU - Holm, René

AU - Selen, Arzu

AU - Rades, T.

AU - Müllertz, A.

PY - 2013

Y1 - 2013

KW - Poorly soluble drugs

KW - Amorphous salt

KW - Furosemide

KW - Biorelevant dissolution

KW - Solubility

KW - Oral bioavailability

U2 - 10.1016/j.ejpb.2013.09.002

DO - 10.1016/j.ejpb.2013.09.002

M3 - Journal article

SN - 0939-6411

VL - 85

SP - 942

EP - 951

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

IS - 3

ER -