Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

Line Hagner Nielsen, Sarah Gordon, René Holm, Arzu Selen, T. Rades, A. Müllertz

Research output: Contribution to journalJournal articleResearchpeer-review

Original languageEnglish
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume85
Issue number3
Pages (from-to)942-951
ISSN0939-6411
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Poorly soluble drugs
  • Amorphous salt
  • Furosemide
  • Biorelevant dissolution
  • Solubility
  • Oral bioavailability

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