A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.
|Journal||J. Labelled Cpd. Radiopharm.|
|Publication status||Published - 1999|
Lundt, I., Malle, B. M., Foged, C., & Valsborg, J. S. (1999). Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis. J. Labelled Cpd. Radiopharm., 42, 1145-1159.