Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis

Inge Lundt, Birgitte Mølholm Malle, Christian Foged, Jacob S. Valsborg

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.
    Original languageEnglish
    JournalJ. Labelled Cpd. Radiopharm.
    Volume42
    Pages (from-to)1145-1159
    Publication statusPublished - 1999

    Cite this

    Lundt, Inge ; Malle, Birgitte Mølholm ; Foged, Christian ; Valsborg, Jacob S. / Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis. In: J. Labelled Cpd. Radiopharm. 1999 ; Vol. 42. pp. 1145-1159.
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    title = "Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis",
    abstract = "A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.",
    author = "Inge Lundt and Malle, {Birgitte M{\o}lholm} and Christian Foged and Valsborg, {Jacob S.}",
    year = "1999",
    language = "English",
    volume = "42",
    pages = "1145--1159",
    journal = "J. Labelled Cpd. Radiopharm.",

    }

    Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis. / Lundt, Inge; Malle, Birgitte Mølholm; Foged, Christian; Valsborg, Jacob S.

    In: J. Labelled Cpd. Radiopharm., Vol. 42, 1999, p. 1145-1159.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis

    AU - Lundt, Inge

    AU - Malle, Birgitte Mølholm

    AU - Foged, Christian

    AU - Valsborg, Jacob S.

    PY - 1999

    Y1 - 1999

    N2 - A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.

    AB - A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.

    M3 - Journal article

    VL - 42

    SP - 1145

    EP - 1159

    JO - J. Labelled Cpd. Radiopharm.

    JF - J. Labelled Cpd. Radiopharm.

    ER -