Preparation of 14-C-labelled
                1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic
                Imines using KCN in a One-Pot Synthesis

Inge Lundt; Birgitte Mølholm Malle; Christian Foged; Jacob S. Valsborg

Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis

Inge Lundt, Birgitte Mølholm Malle, Christian Foged, Jacob S. Valsborg

Novo Nordisk Foundation

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.

Original language	English
Journal	J. Labelled Cpd. Radiopharm.
Volume	42
Pages (from-to)	1145-1159
Publication status	Published - 1999

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@article{1ffecc5cc4ad4d7d9d6cd1d716b3093c,

title = "Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis",

abstract = "A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.",

author = "Inge Lundt and Malle, {Birgitte M{\o}lholm} and Christian Foged and Valsborg, {Jacob S.}",

year = "1999",

language = "English",

volume = "42",

pages = "1145--1159",

journal = "J. Labelled Cpd. Radiopharm.",

}

Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis. / Lundt, Inge; Malle, Birgitte Mølholm; Foged, Christian et al.
In: J. Labelled Cpd. Radiopharm., Vol. 42, 1999, p. 1145-1159.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis

AU - Lundt, Inge

AU - Malle, Birgitte Mølholm

AU - Foged, Christian

AU - Valsborg, Jacob S.

PY - 1999

Y1 - 1999

N2 - A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.

AB - A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.

M3 - Journal article

VL - 42

SP - 1145

EP - 1159

JO - J. Labelled Cpd. Radiopharm.

JF - J. Labelled Cpd. Radiopharm.

ER -