Preparation of 14-C-labelled 1,4-Dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of Cyclic Imines using KCN in a One-Pot Synthesis

Inge Lundt, Birgitte Mølholm Malle, Christian Foged, Jacob S. Valsborg

    Research output: Contribution to journalJournal articleResearchpeer-review


    A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI2. This method was used to prepare the potent -glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol 14-C labelled at C-5.Keywords: in situ cyanosilylation; 14-C labelled hydroxylated pyrrolidines; glycosidase inhibitors.
    Original languageEnglish
    JournalJ. Labelled Cpd. Radiopharm.
    Pages (from-to)1145-1159
    Publication statusPublished - 1999

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