Preparation and aqueous solution properties of new thermoresponsive biocompatible ABA triblock copolymer gelators

Peter Jeppe Madsen; Steven P. Armes; Andrew L. Lewis

doi:10.1021/ma062198z

Preparation and aqueous solution properties of new thermoresponsive biocompatible ABA triblock copolymer gelators

Peter Jeppe Madsen, Steven P. Armes, Andrew L. Lewis

Research output: Contribution to journal › Journal article › Communication

Abstract

The synthesis and aqueous gelation behavior of ABA triblock copolymers, in which the hydrophobic character of the A block is systematically varied were investigated. Three types pf ABA triblock copolymers of approximately the same overall composition were prepared in which the A block is either poly(methyl methacrylate) or poly(2-hydroxyethyl methacrylate). Each of these copolymers was synthesized by ATRP in methanol using sequential monomer addition. The results showed that the viscosity of a 10% w/v aqueous solution of the copolymers unexpectedly increased by almost 2 orders of magnitude on heating from 0°C to 30°C. The analogous PHEMA-based triblock copolymer is found to be too hydrophobic to undergo efficient gelation, while the PMMA-based triblock copolymers cannot be molecularly dissolved/dispersed in water under any conditions.

Original language	English
Journal	Macromolecules
Volume	39
Issue number	22
Pages (from-to)	7455-7457
Number of pages	3
ISSN	0024-9297
DOIs	https://doi.org/10.1021/ma062198z
Publication status	Published - 2006
Externally published	Yes

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title = "Preparation and aqueous solution properties of new thermoresponsive biocompatible ABA triblock copolymer gelators",

abstract = "The synthesis and aqueous gelation behavior of ABA triblock copolymers, in which the hydrophobic character of the A block is systematically varied were investigated. Three types pf ABA triblock copolymers of approximately the same overall composition were prepared in which the A block is either poly(methyl methacrylate) or poly(2-hydroxyethyl methacrylate). Each of these copolymers was synthesized by ATRP in methanol using sequential monomer addition. The results showed that the viscosity of a 10% w/v aqueous solution of the copolymers unexpectedly increased by almost 2 orders of magnitude on heating from 0°C to 30°C. The analogous PHEMA-based triblock copolymer is found to be too hydrophobic to undergo efficient gelation, while the PMMA-based triblock copolymers cannot be molecularly dissolved/dispersed in water under any conditions.",

author = "{Jeppe Madsen}, Peter and Armes, {Steven P.} and Lewis, {Andrew L.}",

year = "2006",

doi = "10.1021/ma062198z",

language = "English",

volume = "39",

pages = "7455--7457",

journal = "Macromolecules",

issn = "0024-9297",

publisher = "American Chemical Society",

number = "22",

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TY - JOUR

T1 - Preparation and aqueous solution properties of new thermoresponsive biocompatible ABA triblock copolymer gelators

AU - Jeppe Madsen, Peter

AU - Armes, Steven P.

AU - Lewis, Andrew L.

PY - 2006

Y1 - 2006

N2 - The synthesis and aqueous gelation behavior of ABA triblock copolymers, in which the hydrophobic character of the A block is systematically varied were investigated. Three types pf ABA triblock copolymers of approximately the same overall composition were prepared in which the A block is either poly(methyl methacrylate) or poly(2-hydroxyethyl methacrylate). Each of these copolymers was synthesized by ATRP in methanol using sequential monomer addition. The results showed that the viscosity of a 10% w/v aqueous solution of the copolymers unexpectedly increased by almost 2 orders of magnitude on heating from 0°C to 30°C. The analogous PHEMA-based triblock copolymer is found to be too hydrophobic to undergo efficient gelation, while the PMMA-based triblock copolymers cannot be molecularly dissolved/dispersed in water under any conditions.

AB - The synthesis and aqueous gelation behavior of ABA triblock copolymers, in which the hydrophobic character of the A block is systematically varied were investigated. Three types pf ABA triblock copolymers of approximately the same overall composition were prepared in which the A block is either poly(methyl methacrylate) or poly(2-hydroxyethyl methacrylate). Each of these copolymers was synthesized by ATRP in methanol using sequential monomer addition. The results showed that the viscosity of a 10% w/v aqueous solution of the copolymers unexpectedly increased by almost 2 orders of magnitude on heating from 0°C to 30°C. The analogous PHEMA-based triblock copolymer is found to be too hydrophobic to undergo efficient gelation, while the PMMA-based triblock copolymers cannot be molecularly dissolved/dispersed in water under any conditions.

U2 - 10.1021/ma062198z

DO - 10.1021/ma062198z

M3 - Journal article

VL - 39

SP - 7455

EP - 7457

JO - Macromolecules

JF - Macromolecules

SN - 0024-9297

IS - 22

ER -

Preparation and aqueous solution properties of new thermoresponsive biocompatible ABA triblock copolymer gelators

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