Preliminary characterisation of Toxoplasma gondii isolates from Zimbabwe, with stage-specific monoclonal antibodies

T. Hove, Peter Lind, S. Mukaratirwa

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Cell-culture-derived clones of eight Toxoplasma gondii isolates from Zimbabwe were characterised in IFAT with a panel of five monoclonal antibodies (mAb). Each clone had been established from a single murine brain cyst. The antibodies were bradyzoite-specific (4.3), tachyzoite-specific (4.25, 5.1 and anti-P-30), or tachyzoite- and bradyzoite-specific (5.15). Their strong reactivity with the bradyzoite-specific mAb 4.3 and their weaker reactivity with the tachyzoite-specific 4.25, 5.1 and anti-P-30 indicated that all the isolates are probably of genetic type II. Each of the isolates reacted in the IFAT in a similar way to the Danish reference strain of T. gondii, SSI-119.
    Original languageEnglish
    JournalAnnals of Tropical Medicine and Parasitology
    Volume99
    Issue number4
    Pages (from-to)377-382
    ISSN0003-4983
    DOIs
    Publication statusPublished - 2005

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