Prediction of Antibody Epitopes

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    Abstract

    Antibodies recognize their cognate antigens in a precise and effective way. In order to do so, they target regions of the antigenic molecules that have specific features such as large exposed areas, presence of charged or polar atoms, specific secondary structure elements, and lack of similarity to self-proteins. Given the sequence or the structure of a protein of interest, several methods exploit such features to predict the residues that are more likely to be recognized by an immunoglobulin.Here, we present two methods (BepiPred and DiscoTope) to predict linear and discontinuous antibody epitopes from the sequence and/or the three-dimensional structure of a target protein.
    Original languageEnglish
    Title of host publicationPeptide Antibodies
    Number of pages10
    Volume1348
    PublisherSpringer
    Publication date2015
    Pages23-32
    Chapter4
    ISBN (Print)978-1-4939-2998-6
    ISBN (Electronic)978-1-4939-2999-3
    DOIs
    Publication statusPublished - 2015
    SeriesMethods in Molecular Biology
    ISSN1064-3745

    Keywords

    • Discontinuous epitope
    • Epitope
    • Linear epitope
    • Prediction

    Cite this

    Nielsen, M., & Marcatili, P. (2015). Prediction of Antibody Epitopes. In Peptide Antibodies (Vol. 1348, pp. 23-32). Springer. Methods in Molecular Biology https://doi.org/10.1007/978-1-4939-2999-3_4