Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI

Jean C. Augustinack, Kristen E. Huber, Allison A. Stevens, Michelle Roy, Matthew P. Frosch, André J.W. van der Kouwe, Lawrence L. Wald, Koen Van Leemput, Ann C. McKee, Bruce Fischl

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The perirhinal cortex (Brodmann's area 35) is a multimodal area that is important for normal memory function. Specifically, perirhinal cortex is involved in the detection of novel objects and manifests neurofibrillary tangles in Alzheimer's disease very early in disease progression. We scanned ex vivo brain hemispheres at standard resolution (1mm×1mm×1mm) to construct pial/white matter surfaces in FreeSurfer and scanned again at high resolution (120μm×120μm×120μm) to determine cortical architectural boundaries. After labeling perirhinal area 35 in the high resolution images, we mapped the high resolution labels to the surface models to localize area 35 in fourteen cases. We validated the area boundaries determined using histological Nissl staining. To test the accuracy of the probabilistic mapping, we measured the Hausdorff distance between the predicted and true labels and found that the median Hausdorff distance was 4.0mm for the left hemispheres (n=7) and 3.2mm for the right hemispheres (n=7) across subjects. To show the utility of perirhinal localization, we mapped our labels to a subset of the Alzheimer's Disease Neuroimaging Initiative dataset and found decreased cortical thickness measures in mild cognitive impairment and Alzheimer's disease compared to controls in the predicted perirhinal area 35. Our ex vivo probabilistic mapping of the perirhinal cortex provides histologically validated, automated and accurate labeling of architectonic regions in the medial temporal lobe, and facilitates the analysis of atrophic changes in a large dataset for earlier detection and diagnosis.
Original languageEnglish
JournalNeuroImage
Volume64
Pages (from-to)32-42
ISSN1053-8119
DOIs
Publication statusPublished - 2013

Keywords

  • Morphometry
  • Mesocortex
  • Alzheimer's disease
  • Localization

Cite this

Augustinack, J. C., Huber, K. E., Stevens, A. A., Roy, M., Frosch, M. P., van der Kouwe, A. J. W., ... Fischl, B. (2013). Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI. NeuroImage, 64, 32-42. https://doi.org/10.1016/j.neuroimage.2012.08.071
Augustinack, Jean C. ; Huber, Kristen E. ; Stevens, Allison A. ; Roy, Michelle ; Frosch, Matthew P. ; van der Kouwe, André J.W. ; Wald, Lawrence L. ; Van Leemput, Koen ; McKee, Ann C. ; Fischl, Bruce. / Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI. In: NeuroImage. 2013 ; Vol. 64. pp. 32-42.
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abstract = "The perirhinal cortex (Brodmann's area 35) is a multimodal area that is important for normal memory function. Specifically, perirhinal cortex is involved in the detection of novel objects and manifests neurofibrillary tangles in Alzheimer's disease very early in disease progression. We scanned ex vivo brain hemispheres at standard resolution (1mm×1mm×1mm) to construct pial/white matter surfaces in FreeSurfer and scanned again at high resolution (120μm×120μm×120μm) to determine cortical architectural boundaries. After labeling perirhinal area 35 in the high resolution images, we mapped the high resolution labels to the surface models to localize area 35 in fourteen cases. We validated the area boundaries determined using histological Nissl staining. To test the accuracy of the probabilistic mapping, we measured the Hausdorff distance between the predicted and true labels and found that the median Hausdorff distance was 4.0mm for the left hemispheres (n=7) and 3.2mm for the right hemispheres (n=7) across subjects. To show the utility of perirhinal localization, we mapped our labels to a subset of the Alzheimer's Disease Neuroimaging Initiative dataset and found decreased cortical thickness measures in mild cognitive impairment and Alzheimer's disease compared to controls in the predicted perirhinal area 35. Our ex vivo probabilistic mapping of the perirhinal cortex provides histologically validated, automated and accurate labeling of architectonic regions in the medial temporal lobe, and facilitates the analysis of atrophic changes in a large dataset for earlier detection and diagnosis.",
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author = "Augustinack, {Jean C.} and Huber, {Kristen E.} and Stevens, {Allison A.} and Michelle Roy and Frosch, {Matthew P.} and {van der Kouwe}, {Andr{\'e} J.W.} and Wald, {Lawrence L.} and {Van Leemput}, Koen and McKee, {Ann C.} and Bruce Fischl",
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Augustinack, JC, Huber, KE, Stevens, AA, Roy, M, Frosch, MP, van der Kouwe, AJW, Wald, LL, Van Leemput, K, McKee, AC & Fischl, B 2013, 'Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI', NeuroImage, vol. 64, pp. 32-42. https://doi.org/10.1016/j.neuroimage.2012.08.071

Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI. / Augustinack, Jean C.; Huber, Kristen E.; Stevens, Allison A.; Roy, Michelle; Frosch, Matthew P.; van der Kouwe, André J.W.; Wald, Lawrence L.; Van Leemput, Koen; McKee, Ann C.; Fischl, Bruce.

In: NeuroImage, Vol. 64, 2013, p. 32-42.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI

AU - Augustinack, Jean C.

AU - Huber, Kristen E.

AU - Stevens, Allison A.

AU - Roy, Michelle

AU - Frosch, Matthew P.

AU - van der Kouwe, André J.W.

AU - Wald, Lawrence L.

AU - Van Leemput, Koen

AU - McKee, Ann C.

AU - Fischl, Bruce

PY - 2013

Y1 - 2013

N2 - The perirhinal cortex (Brodmann's area 35) is a multimodal area that is important for normal memory function. Specifically, perirhinal cortex is involved in the detection of novel objects and manifests neurofibrillary tangles in Alzheimer's disease very early in disease progression. We scanned ex vivo brain hemispheres at standard resolution (1mm×1mm×1mm) to construct pial/white matter surfaces in FreeSurfer and scanned again at high resolution (120μm×120μm×120μm) to determine cortical architectural boundaries. After labeling perirhinal area 35 in the high resolution images, we mapped the high resolution labels to the surface models to localize area 35 in fourteen cases. We validated the area boundaries determined using histological Nissl staining. To test the accuracy of the probabilistic mapping, we measured the Hausdorff distance between the predicted and true labels and found that the median Hausdorff distance was 4.0mm for the left hemispheres (n=7) and 3.2mm for the right hemispheres (n=7) across subjects. To show the utility of perirhinal localization, we mapped our labels to a subset of the Alzheimer's Disease Neuroimaging Initiative dataset and found decreased cortical thickness measures in mild cognitive impairment and Alzheimer's disease compared to controls in the predicted perirhinal area 35. Our ex vivo probabilistic mapping of the perirhinal cortex provides histologically validated, automated and accurate labeling of architectonic regions in the medial temporal lobe, and facilitates the analysis of atrophic changes in a large dataset for earlier detection and diagnosis.

AB - The perirhinal cortex (Brodmann's area 35) is a multimodal area that is important for normal memory function. Specifically, perirhinal cortex is involved in the detection of novel objects and manifests neurofibrillary tangles in Alzheimer's disease very early in disease progression. We scanned ex vivo brain hemispheres at standard resolution (1mm×1mm×1mm) to construct pial/white matter surfaces in FreeSurfer and scanned again at high resolution (120μm×120μm×120μm) to determine cortical architectural boundaries. After labeling perirhinal area 35 in the high resolution images, we mapped the high resolution labels to the surface models to localize area 35 in fourteen cases. We validated the area boundaries determined using histological Nissl staining. To test the accuracy of the probabilistic mapping, we measured the Hausdorff distance between the predicted and true labels and found that the median Hausdorff distance was 4.0mm for the left hemispheres (n=7) and 3.2mm for the right hemispheres (n=7) across subjects. To show the utility of perirhinal localization, we mapped our labels to a subset of the Alzheimer's Disease Neuroimaging Initiative dataset and found decreased cortical thickness measures in mild cognitive impairment and Alzheimer's disease compared to controls in the predicted perirhinal area 35. Our ex vivo probabilistic mapping of the perirhinal cortex provides histologically validated, automated and accurate labeling of architectonic regions in the medial temporal lobe, and facilitates the analysis of atrophic changes in a large dataset for earlier detection and diagnosis.

KW - Morphometry

KW - Mesocortex

KW - Alzheimer's disease

KW - Localization

U2 - 10.1016/j.neuroimage.2012.08.071

DO - 10.1016/j.neuroimage.2012.08.071

M3 - Journal article

C2 - 22960087

VL - 64

SP - 32

EP - 42

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -

Augustinack JC, Huber KE, Stevens AA, Roy M, Frosch MP, van der Kouwe AJW et al. Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI. NeuroImage. 2013;64:32-42. https://doi.org/10.1016/j.neuroimage.2012.08.071