Predicting the location of entorhinal cortex from MRI

B. Fischl, A. A. Stevens, N. Rajendran, B. T. Yeo, D. N. Greve, Koen Van Leemput, J. R. Polimeni, S. Kakunoori, R. L. Buckner, J. Pacheco

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Entorhinal cortex (EC) is a medial temporal lobe area critical to memory formation and spatial navigation that is among the earliest parts of the brain affected by Alzheimer's disease (AD). Accurate localization of EC would thus greatly facilitate early detection and diagnosis of AD. In this study, we used ultra-high resolution ex vivo MRI to directly visualize the architectonic features that define EC rostrocaudally and mediolaterally, then applied surface-based registration techniques to quantify the variability of EC with respect to cortical geometry, and made predictions of its location on in vivo scans. The results indicate that EC can be localized quite accurately based on cortical folding patterns, within 3 mm in vivo, a significant step forward in our ability to detect the earliest effects of AD when clinical intervention is most likely to be effective.
Original languageEnglish
JournalNeuroImage
Volume47
Issue number1
Pages (from-to)8-17
ISSN1053-8119
DOIs
Publication statusPublished - 2009
Externally publishedYes

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