Predicting Subcellular Localization of Proteins by Bioinformatic Algorithms

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    Abstract

    When predicting the subcellular localization of proteins from their amino acid sequences, there are basically three approaches: signal-based, global property-based, and homology-based. Each of these has its advantages and drawbacks, and it is important when comparing methods to know which approach was used. Various statistical and machine learning algorithms are used with all three approaches, and various measures and standards are employed when reporting the performances of the developed methods. This chapter presents a number of available methods for prediction of sorting signals and subcellular localization, but rather than providing a checklist of which predictors to use, it aims to function as a guide for critical assessment of prediction methods.
    Original languageEnglish
    Title of host publicationProtein Export in Gram-positive Bacteria
    EditorsF. Bagnoli, R. Rappuoli
    Number of pages30
    PublisherSpringer
    Publication date2015
    DOIs
    Publication statusPublished - 2015
    SeriesCurrent Topics in Microbiology and Immunology
    ISSN0070-217X

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