TY - JOUR
T1 - Predicting and rationalizing the effect of surface charge distribution and orientation on nano-wire based FET bio-sensors
AU - De Vico, L.
AU - Iversen, L.
AU - Sørensen, Martin Hedegård
AU - Brandbyge, Mads
AU - Nygard, J.
AU - Martinez, K.L.
AU - Jensen, J.H.
PY - 2011
Y1 - 2011
N2 - A single charge screening model of surface charge sensors in liquids (De Vico et al., Nanoscale, 2011, 3, 706-717) is extended to multiple charges to model the effect of the charge distributions of analyte proteins on FET sensor response. With this model we show that counter-intuitive signal changes (e.g. a positive signal change due to a net positive protein binding to a p-type conductor) can occur for certain combinations of charge distributions and Debye lengths. The new method is applied to interpret published experimental data on Streptavidin (Ishikawa et al., ACS Nano, 2009, 3, 3969-3976) and Nucleocapsid protein (Ishikawa et al., ACS Nano, 2009, 3, 1219-1224).
AB - A single charge screening model of surface charge sensors in liquids (De Vico et al., Nanoscale, 2011, 3, 706-717) is extended to multiple charges to model the effect of the charge distributions of analyte proteins on FET sensor response. With this model we show that counter-intuitive signal changes (e.g. a positive signal change due to a net positive protein binding to a p-type conductor) can occur for certain combinations of charge distributions and Debye lengths. The new method is applied to interpret published experimental data on Streptavidin (Ishikawa et al., ACS Nano, 2009, 3, 3969-3976) and Nucleocapsid protein (Ishikawa et al., ACS Nano, 2009, 3, 1219-1224).
U2 - 10.1039/c1nr10316d
DO - 10.1039/c1nr10316d
M3 - Journal article
C2 - 21811738
SN - 2040-3364
VL - 3
SP - 3635
EP - 3640
JO - Nanoscale
JF - Nanoscale
IS - 9
ER -