Abstract
| Original language | English |
|---|---|
| Journal | International Journal of Obesity |
| Number of pages | 4 |
| ISSN | 0307-0565 |
| DOIs | |
| Publication status | Published - 2017 |
Cite this
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Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention. / Hjorth, M F; Roager, Henrik Munch; Larsen, T. M.; Poulsen, S K; Licht, Tine Rask; Bahl, Martin Iain; Zohar, Y; Astrup, A.
In: International Journal of Obesity, 2017.Research output: Contribution to journal › Conference article › Research › peer-review
TY - GEN
T1 - Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention
AU - Hjorth, M F
AU - Roager, Henrik Munch
AU - Larsen, T. M.
AU - Poulsen, S K
AU - Licht, Tine Rask
AU - Bahl, Martin Iain
AU - Zohar, Y
AU - Astrup, A.
PY - 2017
Y1 - 2017
N2 - Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI −0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.
AB - Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI −0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.
U2 - 10.1038/ijo.2017.220
DO - 10.1038/ijo.2017.220
M3 - Conference article
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
ER -