Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention

M F Hjorth*, Henrik Munch Roager, T. M. Larsen, S K Poulsen, Tine Rask Licht, Martin Iain Bahl, Y Zohar, A. Astrup

*Corresponding author for this work

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Abstract

Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI −0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.
Original languageEnglish
JournalInternational Journal of Obesity
Number of pages4
ISSN0307-0565
DOIs
Publication statusPublished - 2017

Cite this

@inproceedings{cf745868a66a4ba18c2eaf48e9bb5e71,
title = "Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention",
abstract = "Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95{\%}CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95{\%} CI −0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95{\%}CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.",
author = "Hjorth, {M F} and Roager, {Henrik Munch} and Larsen, {T. M.} and Poulsen, {S K} and Licht, {Tine Rask} and Bahl, {Martin Iain} and Y Zohar and A. Astrup",
year = "2017",
doi = "10.1038/ijo.2017.220",
language = "English",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",

}

Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention. / Hjorth, M F; Roager, Henrik Munch; Larsen, T. M.; Poulsen, S K; Licht, Tine Rask; Bahl, Martin Iain; Zohar, Y; Astrup, A.

In: International Journal of Obesity, 2017.

Research output: Contribution to journalConference articleResearchpeer-review

TY - GEN

T1 - Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention

AU - Hjorth, M F

AU - Roager, Henrik Munch

AU - Larsen, T. M.

AU - Poulsen, S K

AU - Licht, Tine Rask

AU - Bahl, Martin Iain

AU - Zohar, Y

AU - Astrup, A.

PY - 2017

Y1 - 2017

N2 - Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI −0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.

AB - Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI −0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.

U2 - 10.1038/ijo.2017.220

DO - 10.1038/ijo.2017.220

M3 - Conference article

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -