PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

Rasmus Koefoed Petersen, Signe Benzon Larsen, Ditte Marie Jensen, Jane Christensen, Anja Olsen, Steffen Loft, Christine Lydia Nellemann, Kim Overvad, Karsten Kristiansen, Anne Tjønneland, Ulla Birgitte Vogel

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPARγ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro12Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPARγ and the PPARγ-PGC-1α complex was inhibited by ethanol. PPARγ 12Ala-mediated transcription activation was not enhanced by PGC-1α, resulting in allele-specific transcription activation by the PPARγ 12Pro-PGC-1α complex. Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer.
Original languageEnglish
JournalCancer Letters
Volume315
Issue number1
Pages (from-to)59-68
ISSN0304-3835
DOIs
Publication statusPublished - 2012

Cite this

Koefoed Petersen, R., Benzon Larsen, S., Jensen, D. M., Christensen, J., Olsen, A., Loft, S., Nellemann, C. L., Overvad, K., Kristiansen, K., Tjønneland, A., & Vogel, U. B. (2012). PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. Cancer Letters, 315(1), 59-68. https://doi.org/10.1016/j.canlet.2011.10.009