Post-translational modification-dependent activity of matrix metalloproteinases

Elizabeta Madzharova, Philipp Kastl, Fabio Sabino, Ulrich auf dem Keller*

*Corresponding author for this work

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Due to their capacity to process different proteins of the extracellular matrix (ECM), matrix metalloproteinases (MMPs) were initially described as a family of secreted proteases, functioning as main ECM regulators. However, through proteolytic processing of various biomolecules, MMPs also modulate intra- and extracellular pathways and networks. Thereby, they are functionally implicated in the regulation of multiple physiological and pathological processes. Consequently, MMP activity is tightly regulated through a combination of epigenetic, transcriptional, and post-transcriptional control of gene expression, proteolytic activation, post-translational modifications (PTMs), and extracellular inhibition. In addition, MMPs, their substrates and ECM binding partners are frequently modified by PTMs, which suggests an important role of PTMs in modulating the pleiotropic activities of these proteases. This review summarizes the recent progress towards understanding the role of PTMs (glycosylation, phosphorylation, glycosaminoglycans) on the activity of several members of the MMP family.

Original languageEnglish
Article number3077
JournalInternational Journal of Molecular Sciences
Issue number12
Number of pages18
Publication statusPublished - 2019


  • Glycosaminoglycans
  • Glycosylation
  • MMPs
  • Phosphorylation
  • PTMs


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