Possibly enhanced Gd-excretion in dialysate, but no clinical benefit of 3-5 months treatment with sodium thiosulfate in nephrogenic systemic fibrosis

P. Marckmann, A.H. Nielsen, Jens Jørgen Sloth

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background. Gd-related nephrogenic systemic fibrosis was successfully treated with intravenous sodium thiosulfate according to a recent case report. Methods. Four haemodialysis patients with severe Gd-related nephrogenic systemic fibrosis were treated with intravenous sodium thiosulfate for 3-5 months. Symptoms and patients' experiences were investigated. The dialysate Gd content was monitored. Results. We observed no major clinical improvements in any patient. In one patient, we found slightly improved joint motion. Two patients had a subjective impression of slight improvements of joint motion and skin abnormalities. The dialysate Gd content was raised by the treatment, up to fivefold. Conclusions. We could not confirm that sodium thiosulfate treatment results in marked and rapid improvement in late stages of Gd-related nephrogenic systemic fibrosis. However, dialysate contents of Gd seemed to increase. It is unknown whether increased Gd excretion will lead to long-term clinical improvements in late stages of nephrogenic systemic fibrosis.
Original languageEnglish
JournalNephrology, Dialysis, Transplantation
Volume23
Issue number10
Pages (from-to)3280-3282
ISSN0931-0509
DOIs
Publication statusPublished - 2008

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