Population pharmacokinetic modeling of a subcutaneous depot for GnRH antagonist degarelix

Christoffer Wenzel Tornøe, Henrik Agersø, Henrik Aalborg Nielsen, Henrik Madsen, E. Niclas Jonsson

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    Abstract

    Purpose. The objective of this study is to develop a population pharmacokinetic (PK) model that describes the subcutaneous (SC) depot formation of gonadotropin-releasing hormone (GnRH) antagonist degarelix, which is being developed for treatment of prostate cancer, exhibiting dose-volume and dose-concentration dependent absorption. Methods. The PK analysis is made in NONMEM through joint analysis of data from two phase I clinical studies; an intravenous infusion study and a single SC dose escalation study. The SC absorption is modeled using an approximation to Ficks' second law of diffusion out of a spherical depot. The dose-volume effect on the SC release is estimated using a B-spline basis whereas the bioavailability is modeled as a function of the dose-concentration. Results. The SC depot model is approximated by using two concentric spherical compartments for the SC absorption combined with a two-compartment disposition model. The results indicate that the volume effect is most apparent at low injection volumes whereas the effect is diminishing at higher injection volumes. The dose-concentration effect on the bioavailability is estimated to decrease at increasing dose-concentrations. Conclusions. The presented SC depot model describes the PK profile of GnRH antagonist degarelix. This modeling approach might also be applicable for other depot-formulated drugs exhibiting complex PK profiles.
    Original languageEnglish
    Publication date2003
    Publication statusPublished - 2003
    EventPAGE Meeting 2003 - Verona, Italy
    Duration: 12 Jun 200313 Jun 2003

    Conference

    ConferencePAGE Meeting 2003
    CountryItaly
    CityVerona
    Period12/06/200313/06/2003

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