Population genetic differentiation of height and body mass index across Europe

Matthew R. Robinson, Gibran Hemani, Carolina Medina-Gomez, Massimo Mezzavilla, Tonu Esko, Konstantin Shakhbazov, Joseph E. Powell, Anna Vinkhuyzen, Sonja I. Berndt, Stefan Gustafsson, Tune Hannes Pers, Thomas M. Werge

    Research output: Contribution to journalLetterResearchpeer-review

    Abstract

    Across-nation differences in the mean values for complex traits are common(1-8), but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P <3.94 x 10-8; BMI, P <5.95 x 10-4), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P <0.001), but environmental differences across Europe masked genetic differentiation for BMI (P <0.58).
    Original languageEnglish
    JournalNature Genetics
    Volume47
    Issue number11
    Pages (from-to)1357-1362
    Number of pages8
    ISSN1061-4036
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Genetics research
    • Genome-wide association studies
    • Population genetics

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