Population dynamics of Trichuris suis in trickle-infected pigs

P. Nejsum, S. M. Thamsborg, Heidi Huus Petersen, H. Kringel, M. Fredholm, A. Roepstorff

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The population dynamics of Trichuris suis in pigs as studied during long-term experimental infections. Twenty-three 10-week-old pigs were inoculated with 5 T. suis eggs/kg/day. Seven, 8, and 8 pigs were necropsied at weeks 4,8, and 14 post-start of infection (p.i.), respectively. The median numbers of worms in the colon were 538 (thin-mats: 277-618), 332 (14-1140) and 0 (0-4) at 4, 8, and 14 weeks p.i. respectively, suggesting an increased aggregation of the worms with time and acquitsition of nearly sterile immunity. The serum levels of T. suis specific antibodies (IgG1, IgG2 and IgA) peaked at week 8 p.i. By week 14 p.i. the IgG2 and IgA antibody levels remained significantly elevated above the level of week 0. The population dynamics of T. suis trickle infections ill pigs is discussed with focus on interpretaion of diagnostic and epidemiological data of pigs, the use of pigs as a model for human Trichuris trichiura infections and the novel :approach of tiling T. suis eggs in the treatment of patients with infammatory bowel disease.
Original languageEnglish
JournalParasitology
Volume136
Issue number6
Pages (from-to)691-697
Number of pages7
ISSN0031-1820
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • PARASITOLOGY
  • OESOPHAGOSTOMUM DENTATUM INFECTIONS
  • INTESTINAL NEMATODE INFECTIONS
  • 3 DOSE LEVELS
  • ASCARIS-SUUM
  • HELMINTH INFECTIONS
  • PARASITES
  • PREVALENCE
  • TRICHIURA
  • RESPONSES
  • KINETICS
  • Trichuris suis
  • pig
  • pollution dynamics
  • trickle infection
  • aggregation
  • ELISA
  • Animals
  • Antibodies, Helminth
  • Feces
  • Female
  • Immunoglobulin A
  • Immunoglobulin G
  • Male
  • Parasite Egg Count
  • Population Dynamics
  • Swine
  • Swine Diseases
  • Time Factors
  • Trichuriasis
  • Trichuris
  • immunoglobulin A antibody
  • immunoglobulin G antibody
  • immunoglobulin G1 antibody
  • immunoglobulin G2
  • immunoglobulin g2 antibody
  • unclassified drug
  • helminth antibody
  • immunoglobulin A
  • immunoglobulin G
  • animal experiment
  • animal model
  • antibody specificity
  • article
  • blood level
  • colon
  • controlled study
  • enteritis
  • enzyme linked immunosorbent assay
  • experimental infection
  • female
  • immunity
  • inoculation
  • male
  • nonhuman
  • parasite isolation
  • parasitemia
  • population dynamics
  • priority journal
  • swine
  • trichuriasis
  • trichuris suis
  • animal
  • animal disease
  • blood
  • feces
  • parasite identification
  • parasitology
  • physiology
  • swine disease
  • time
  • Suidae
  • Trichuris trichiura
  • Aggregation
  • Pig
  • Population dynamics
  • Trickle infection
  • pig farm
  • Trichuris suis infection parasitic disease, infectious disease etiology, immunology
  • Artiodactyla Mammalia Vertebrata Chordata Animalia (Animals, Artiodactyls, Chordates, Mammals, Nonhuman Vertebrates, Nonhuman Mammals, Vertebrates) - Suidae [85740] pig common host female, male breed-Duroc, breed-Danish Landrace, breed-Yorkshire
  • Aschelminthes Helminthes Invertebrata Animalia (Animals, Aschelminths, Helminths, Invertebrates) - Nematoda [51300] Trichuris suis species egg parasite
  • IgA antibody immunoglobulin A antibody
  • IgG1 antibody immunoglobulin G1 antibody
  • IgG2 antibody immunoglobulin G2 antibody
  • 10060, Biochemistry studies - General
  • 14004, Digestive system - Physiology and biochemistry
  • 15002, Blood - Blood and lymph studies
  • 15004, Blood - Blood cell studies
  • 34502, Immunology - General and methods
  • 36001, Medical and clinical microbiology - General and methods
  • 60502, Parasitology - General
  • 64016, Invertebrata: comparative, experimental morphology, physiology and pathology - Aschelminthes
  • Ingestion and Assimilation
  • Transport and Circulation
  • colon digestive system
  • serum blood and lymphatics
  • Biochemistry and Molecular Biophysics
  • Blood and Lymphatics
  • Digestive System
  • Parasitology

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