Polymorphisms in the fatty acid desaturase genes and diet are important determinants of infant docosahexaenoic acid status

L. Lauritzen; L. Harsløf; L.H. Larsen; C. Ritz; Lars Hellgren; K. F. Michaelsen; U. Vogel

Polymorphisms in the fatty acid desaturase genes and diet are important determinants of infant docosahexaenoic acid status

L. Lauritzen, L. Harsløf, L.H. Larsen, C. Ritz, Lars Hellgren, K. F. Michaelsen, U. Vogel

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Abstract

Tissue docosahexaenoic acid (DHA) accretion in early infancy is supported by DHA in breast-milk and may thus decrease once complementary feeding
takes over. Endogenous synthesis of DHA from alphalinolenic acid is low and polymorphisms in the genes that encodes the fatty acid desaturases (FADS) has been shown to have little effect on DHA-status in adults. It is unclear to what
extent endogenous DHA-synthesis contributes to infant DHAstatus. We aim to investigate the role of diet and FADS-polymorphisms on DHA-status at 9 months and 3 years. Methods: This cross-sectional study with Danish infants use data from two prospective studies (EFiON and the SKOTcohort). We measured erythrocyte (RBC) DHA-status at 9 months (n=409) and 3 years (n=176) and genotyped 4 FADS tagSNPs, rs3834458, rs1535, rs174575 and rs174448 (n=401).

Original language	English
Article number	PO133
Journal	Annals of Nutrition and Metabolism
Volume	63
Issue number	Suppl. 1
Pages (from-to)	320-321
ISSN	0250-6807
Publication status	Published - 2013
Event	IUNS 20th International Congress of Nutrition - Granada, Spain Duration: 15 Sept 2013 → 20 Sept 2013 Conference number: 20 http://icn2013.com/

Conference

Conference	IUNS 20th International Congress of Nutrition
Number	20
Country/Territory	Spain
City	Granada
Period	15/09/2013 → 20/09/2013
Internet address	http://icn2013.com/

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title = "Polymorphisms in the fatty acid desaturase genes and diet are important determinants of infant docosahexaenoic acid status",

abstract = "Tissue docosahexaenoic acid (DHA) accretion in early infancy is supported by DHA in breast-milk and may thus decrease once complementary feedingtakes over. Endogenous synthesis of DHA from alphalinolenic acid is low and polymorphisms in the genes that encodes the fatty acid desaturases (FADS) has been shown to have little effect on DHA-status in adults. It is unclear to whatextent endogenous DHA-synthesis contributes to infant DHAstatus. We aim to investigate the role of diet and FADS-polymorphisms on DHA-status at 9 months and 3 years. Methods: This cross-sectional study with Danish infants use data from two prospective studies (EFiON and the SKOTcohort). We measured erythrocyte (RBC) DHA-status at 9 months (n=409) and 3 years (n=176) and genotyped 4 FADS tagSNPs, rs3834458, rs1535, rs174575 and rs174448 (n=401).",

author = "L. Lauritzen and L. Harsl{\o}f and L.H. Larsen and C. Ritz and Lars Hellgren and Michaelsen, {K. F.} and U. Vogel",

year = "2013",

language = "English",

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pages = "320--321",

journal = "Annals of Nutrition and Metabolism",

issn = "0250-6807",

publisher = "S. Karger AG",

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TY - ABST

T1 - Polymorphisms in the fatty acid desaturase genes and diet are important determinants of infant docosahexaenoic acid status

AU - Lauritzen, L.

AU - Harsløf, L.

AU - Larsen, L.H.

AU - Ritz, C.

AU - Hellgren, Lars

AU - Michaelsen, K. F.

AU - Vogel, U.

N1 - Conference code: 20

PY - 2013

Y1 - 2013

N2 - Tissue docosahexaenoic acid (DHA) accretion in early infancy is supported by DHA in breast-milk and may thus decrease once complementary feedingtakes over. Endogenous synthesis of DHA from alphalinolenic acid is low and polymorphisms in the genes that encodes the fatty acid desaturases (FADS) has been shown to have little effect on DHA-status in adults. It is unclear to whatextent endogenous DHA-synthesis contributes to infant DHAstatus. We aim to investigate the role of diet and FADS-polymorphisms on DHA-status at 9 months and 3 years. Methods: This cross-sectional study with Danish infants use data from two prospective studies (EFiON and the SKOTcohort). We measured erythrocyte (RBC) DHA-status at 9 months (n=409) and 3 years (n=176) and genotyped 4 FADS tagSNPs, rs3834458, rs1535, rs174575 and rs174448 (n=401).

AB - Tissue docosahexaenoic acid (DHA) accretion in early infancy is supported by DHA in breast-milk and may thus decrease once complementary feedingtakes over. Endogenous synthesis of DHA from alphalinolenic acid is low and polymorphisms in the genes that encodes the fatty acid desaturases (FADS) has been shown to have little effect on DHA-status in adults. It is unclear to whatextent endogenous DHA-synthesis contributes to infant DHAstatus. We aim to investigate the role of diet and FADS-polymorphisms on DHA-status at 9 months and 3 years. Methods: This cross-sectional study with Danish infants use data from two prospective studies (EFiON and the SKOTcohort). We measured erythrocyte (RBC) DHA-status at 9 months (n=409) and 3 years (n=176) and genotyped 4 FADS tagSNPs, rs3834458, rs1535, rs174575 and rs174448 (n=401).

M3 - Conference abstract in journal

SN - 0250-6807

VL - 63

SP - 320

EP - 321

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

IS - Suppl. 1

M1 - PO133

T2 - IUNS 20th International Congress of Nutrition

Y2 - 15 September 2013 through 20 September 2013

ER -

Polymorphisms in the fatty acid desaturase genes and diet are important determinants of infant docosahexaenoic acid status

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Conference

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