Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Peng Ke; Honghao Sun; Mingxing Liu; Zhengding Su; Kanghong Hu; Hongda Zhua; Huilin Guo; Hongmei Sun; Thomas Lars Andresen; Lars Folke Olsen

doi:10.1049/iet-nbt.2014.0070

Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu, Hongda Zhua, Huilin Guo, Hongmei Sun, Thomas Lars Andresen, Lars Folke Olsen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.

Original language	English
Journal	IET Nanobiotechnology
Volume	10
Issue number	1
Pages (from-to)	8-12
Number of pages	5
ISSN	1751-8741
DOIs	https://doi.org/10.1049/iet-nbt.2014.0070
Publication status	Published - 2016

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abstract = "A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.",

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AU - Ke, Peng

AU - Sun, Honghao

AU - Liu, Mingxing

AU - Su, Zhengding

AU - Hu, Kanghong

AU - Zhua, Hongda

AU - Guo, Huilin

AU - Sun, Hongmei

AU - Andresen, Thomas Lars

AU - Olsen, Lars Folke

PY - 2016

Y1 - 2016

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AB - A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.

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DO - 10.1049/iet-nbt.2014.0070

M3 - Journal article

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JO - IET Nanobiotechnology

JF - IET Nanobiotechnology

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Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Abstract

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