Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu, Hongda Zhua, Huilin Guo, Hongmei Sun, Thomas Lars Andresen, Lars Folke Olsen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle. The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.
    Original languageEnglish
    JournalIET Nanobiotechnology
    Volume10
    Issue number1
    Pages (from-to)8-12
    Number of pages5
    ISSN1751-8741
    DOIs
    Publication statusPublished - 2016

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