Polymeric cantilever-based biosensors  with integrated readout

Alicia Johansson; Gabriela Blagoi; Anja Boisen

doi:10.1063/1.2364843

Polymeric cantilever-based biosensors with integrated readout

Alicia Johansson, Gabriela Blagoi, Anja Boisen

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Abstract

The authors present an SU-8 cantilever chip with integrated piezoresistors for detection of surface stress changes due to adsorption of biomolecules on the cantilever surface. Mercaptohexanol is used as a model biomolecule to study molecular interactions with Au-coated SU-8 cantilevers and surface stress changes of about 0.1 N/m are observed. The measurements indicate that the SU-8 surface is inert to mercaptohexanol molecules, which enables the use of a bare SU-8 cantilever as a reference. Moreover, the sensitivity of the cantilevers to pH changes is presented. The results demonstrate that SU-8 cantilevers are a promising alternative to Si-based cantilevers. (c) 2006 American Institute of Physics.

Original language	English
Journal	Applied Physics Letters
Volume	89
Issue number	17
Pages (from-to)	173505
ISSN	0003-6951
DOIs	https://doi.org/10.1063/1.2364843
Publication status	Published - 2006

Bibliographical note

Copyright (2006) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

Keywords

SENSORS

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10.1063/1.2364843

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title = "Polymeric cantilever-based biosensors with integrated readout",

abstract = "The authors present an SU-8 cantilever chip with integrated piezoresistors for detection of surface stress changes due to adsorption of biomolecules on the cantilever surface. Mercaptohexanol is used as a model biomolecule to study molecular interactions with Au-coated SU-8 cantilevers and surface stress changes of about 0.1 N/m are observed. The measurements indicate that the SU-8 surface is inert to mercaptohexanol molecules, which enables the use of a bare SU-8 cantilever as a reference. Moreover, the sensitivity of the cantilevers to pH changes is presented. The results demonstrate that SU-8 cantilevers are a promising alternative to Si-based cantilevers. (c) 2006 American Institute of Physics.",

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AU - Blagoi, Gabriela

AU - Boisen, Anja

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N2 - The authors present an SU-8 cantilever chip with integrated piezoresistors for detection of surface stress changes due to adsorption of biomolecules on the cantilever surface. Mercaptohexanol is used as a model biomolecule to study molecular interactions with Au-coated SU-8 cantilevers and surface stress changes of about 0.1 N/m are observed. The measurements indicate that the SU-8 surface is inert to mercaptohexanol molecules, which enables the use of a bare SU-8 cantilever as a reference. Moreover, the sensitivity of the cantilevers to pH changes is presented. The results demonstrate that SU-8 cantilevers are a promising alternative to Si-based cantilevers. (c) 2006 American Institute of Physics.

AB - The authors present an SU-8 cantilever chip with integrated piezoresistors for detection of surface stress changes due to adsorption of biomolecules on the cantilever surface. Mercaptohexanol is used as a model biomolecule to study molecular interactions with Au-coated SU-8 cantilevers and surface stress changes of about 0.1 N/m are observed. The measurements indicate that the SU-8 surface is inert to mercaptohexanol molecules, which enables the use of a bare SU-8 cantilever as a reference. Moreover, the sensitivity of the cantilevers to pH changes is presented. The results demonstrate that SU-8 cantilevers are a promising alternative to Si-based cantilevers. (c) 2006 American Institute of Physics.

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