Polymer Templating of Supercooled Indomethacin for Polymorph Selection

Scott C. McKellar, Andrew J. Urquhart, Dimitrios A. Lamprou, Alastair J. Florence

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Reported here is a relatively simple technique for polymorph screening of pharmaceutical compounds that are thermally stable. Polymer libraries have previously been used as surfaces to influence, or direct, the crystalline form adopted by an active pharmaceutical ingredient on crystallization from solution. In this current work, we demonstrate the polymorph-directing effect of homopolymer surfaces in the absence of solvent by recrystallization from the supercooled melt. When the nonsteroidal anti-inflammatory drug indomethacin is melted, cooled, and subsequently reheated above its glass transition temperature on an untreated surface, it has a proclivity to crystallize as its δ polymorph. On certain polymer surfaces, however, it preferentially crystallizes as the α polymorph, as a direct result of polymer templating. The method is well-suited to implementation in multiwell plate formats requiring only small amounts of material and enabling multiple experiments to be carried out in parallel with samples readily characterized using X-ray powder diffraction.
Original languageEnglish
JournalA C S Combinatorial Science
Volume14
Issue number3
Pages (from-to)155-159
ISSN2156-8952
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Dive into the research topics of 'Polymer Templating of Supercooled Indomethacin for Polymorph Selection'. Together they form a unique fingerprint.

Cite this