Polymer photonic crystal dye lasers as optofluidic cell sensors

Mads Brøkner Christiansen; Joanna M. Lopacinska; Mogens Havsteen Jakobsen; Niels Asger Mortensen; Hans Martin Dufva; Anders Kristensen

doi:10.1364/OE.17.002722

Polymer photonic crystal dye lasers as optofluidic cell sensors

Mads Brøkner Christiansen
, Joanna M. Lopacinska
, Mogens Havsteen Jakobsen
, Niels Asger Mortensen
, Hans Martin Dufva
, Anders Kristensen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Dye doped hybrid polymer lasers are implemented as label free evanescent field biosensors for detection of cells. It is demonstrated that although the coverage is irregular and the cells extend over several lattice constants, the emission wavelength depends linearly on the fraction of the surface covered by the HeLa cells used as model system. Design parameters relating to photonic crystal sensing of large objects are identified and discussed. The lasers are chemically modified to bind cells and molecules with flexible UV activated linker molecules.

Original language	English
Journal	Optics Express
Volume	17
Issue number	4
Pages (from-to)	2722-2730
ISSN	1094-4087
DOIs	https://doi.org/10.1364/OE.17.002722
Publication status	Published - 2009

Bibliographical note

This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the OSA website - please follow the DOI. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.

Keywords

Photonic Crystals
Biological Sensing and Sensors
Dye Lasers

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10.1364/OE.17.002722

Optics Express v17 n4 2722Final published version, 481 KB

http://www.opticsinfobase.org/abstract.cfm?URI=oe-17-4-2722

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title = "Polymer photonic crystal dye lasers as optofluidic cell sensors",

abstract = "Dye doped hybrid polymer lasers are implemented as label free evanescent field biosensors for detection of cells. It is demonstrated that although the coverage is irregular and the cells extend over several lattice constants, the emission wavelength depends linearly on the fraction of the surface covered by the HeLa cells used as model system. Design parameters relating to photonic crystal sensing of large objects are identified and discussed. The lasers are chemically modified to bind cells and molecules with flexible UV activated linker molecules.",

keywords = "Photonic Crystals, Biological Sensing and Sensors, Dye Lasers",

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note = "This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the OSA website - please follow the DOI. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.",

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doi = "10.1364/OE.17.002722",

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T1 - Polymer photonic crystal dye lasers as optofluidic cell sensors

AU - Christiansen, Mads Brøkner

AU - Lopacinska, Joanna M.

AU - Jakobsen, Mogens Havsteen

AU - Mortensen, Niels Asger

AU - Dufva, Hans Martin

AU - Kristensen, Anders

N1 - This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the OSA website - please follow the DOI. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.

PY - 2009

Y1 - 2009

N2 - Dye doped hybrid polymer lasers are implemented as label free evanescent field biosensors for detection of cells. It is demonstrated that although the coverage is irregular and the cells extend over several lattice constants, the emission wavelength depends linearly on the fraction of the surface covered by the HeLa cells used as model system. Design parameters relating to photonic crystal sensing of large objects are identified and discussed. The lasers are chemically modified to bind cells and molecules with flexible UV activated linker molecules.

AB - Dye doped hybrid polymer lasers are implemented as label free evanescent field biosensors for detection of cells. It is demonstrated that although the coverage is irregular and the cells extend over several lattice constants, the emission wavelength depends linearly on the fraction of the surface covered by the HeLa cells used as model system. Design parameters relating to photonic crystal sensing of large objects are identified and discussed. The lasers are chemically modified to bind cells and molecules with flexible UV activated linker molecules.

KW - Photonic Crystals

KW - Biological Sensing and Sensors

KW - Dye Lasers

U2 - 10.1364/OE.17.002722

DO - 10.1364/OE.17.002722

M3 - Journal article

SN - 1094-4087

VL - 17

SP - 2722

EP - 2730

JO - Optics Express

JF - Optics Express

IS - 4

ER -

Polymer photonic crystal dye lasers as optofluidic cell sensors

Abstract

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Keywords

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