Polyketide synthases as a platform for chemical product design

Amin Zargar, Jesus F. Barajas, Ravi Lal, Jay D. Keasling*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

To reduce the effects of greenhouse gas emissions on climate change, scientific efforts have sought to develop biofuels and bio-based commodity chemicals as petrochemical replacements primarily for their environmental benefits. As the biological design space is far greater than chemical synthesis, there has been a drive to leverage this ability to create and replace fine and specialty chemicals. While polyketide synthases have traditionally been studied for their biosynthesis of pharmaceutical chemicals, the unique advantages of engineering polyketide synthases for the production of biofuels, commodity chemicals, and both pharmaceutical and nonpharmaceutical fine and specialty chemicals are discussed. With our increased understanding of polyketide biosynthetic logic, new computational tools for prospective polyketide synthesis pathways for the creation of existing and novel biochemicals are also outlined.
Original languageEnglish
JournalAIChE Journal
Volume64
Issue number12
Pages (from-to)4201-4207
ISSN0001-1541
DOIs
Publication statusPublished - 2018

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