Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine

Ladan Parhamifar, Anna K. Larsen, A. Christy Hunter, Thomas Lars Andresen, S. Moein Moghimi

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.
    Original languageEnglish
    JournalSoft Matter
    Volume6
    Issue number17
    Pages (from-to)4001-4009
    ISSN1744-683X
    DOIs
    Publication statusPublished - 2010

    Fingerprint Dive into the research topics of 'Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine'. Together they form a unique fingerprint.

    Cite this