Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine

Ladan Parhamifar; Anna K. Larsen; A. Christy Hunter; Thomas Lars Andresen; S. Moein Moghimi

doi:10.1039/c000190b

Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine

Ladan Parhamifar, Anna K. Larsen, A. Christy Hunter, Thomas Lars Andresen, S. Moein Moghimi

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.

Original language	English
Journal	Soft Matter
Volume	6
Issue number	17
Pages (from-to)	4001-4009
ISSN	1744-683X
DOIs	https://doi.org/10.1039/c000190b
Publication status	Published - 2010

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title = "Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine",

abstract = "This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.",

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AU - Larsen, Anna K.

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AU - Andresen, Thomas Lars

AU - Moghimi, S. Moein

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AB - This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.

U2 - 10.1039/c000190b

DO - 10.1039/c000190b

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VL - 6

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JO - Soft Matter

JF - Soft Matter

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Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine

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