Point-of-Care Devices for Pathogen Detections: The Three Most Important Factors to Realize towards Commercialization

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Abstract

The development of lab-on-a-chip technology and its applications in biochemical and biomedical analyses has, during the last two decades, led to the potential realisation of portable and on-site detection devices, the so-called point-of-care (PoC) detection systems. These are essentially cheap, easy-to-handle systems, offering rapid sample-to-answer results to non-technical operators. In this perspective, we do not review all the current advances of Lab-on-a-chip techniques for the realisation of PoC. Instead, we aim to provide insight into what we foresee as the three most important factors to play the essential roles for succeeding in making commercially viable PoC pathogen-detection devices. The three insights are namely: the utilizations of (i) disposable polymer (microfluidic) chips, (ii) the implementation of surface-bound (or solid-phase) nucleic-acid amplification techniques and (iii) relying (more) on open-source hardware and software.
Original languageEnglish
Article number116004
JournalTrends in Analytical Chemistry
Volume131
Number of pages12
ISSN0165-9936
DOIs
Publication statusPublished - 2020

Keywords

  • Point-of-care
  • Lab on a chip
  • LAMP
  • PCR
  • Pathogen
  • Detection
  • Commercialization
  • Polymer injection moulding
  • Solid phase
  • Nucleic acid

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