PMWS Development in Pigs from Affected Farms in Spain and Denmark

L. Grau-Roma, Anders Stockmarr, C. S. Kristensen, Claes Enøe, S. López-Soria, M. Nofrarías, Vivi Bille-Hansen, Charlotte Kristiane Hjulsager, M. Sibila, Sven Erik Lind Jorsal, L. Fraile, P. Baekbo, H. Vigre, J. Segalés, Lars Erik Larsen

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

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Abstract

Postweaning multisystemic wasting syndrome (PMWS) is a worldwide spread condition that affects pigs in nursery and/or fattening units, and is considered to have a severe economic impact on swine production. The main clinical sign of PMWS is wasting, but can also include pallor of the skin, icterus, respiratory distress and diarrhoea. The main essential infectious agent for PMWS development is porcinecircovirus type 2 (PCV2), but the exact cause of PMWS is still unclear.PCV2 is present in most pig herds, but the occurrence of PMWS is more sporadic, and it is been difficult to reproduce PMWS by inoculating PCV2 alone. However, studies where co-infections have been applied have been more successful. Based on this, we modeled PMWS development based on longitudinal data on antibodies and PMWS status from herds in Denmark and Spain, where presence of a range of pathogens were considered as explanatory variables in the form of maternal immunity and the occurrence of seroconversion against the considered pathogens. However, maternal immunity could not be measured from mother animals due to cross fostering, no time points for seroconversion was available, and no case/control status could be assigned as PMWS do not have an ‘infectious period’ after which animals may be assigned control status. The talk will concentrate on the framework in which this was handled, which may be translated to similar settings for similar studies. We found that seroconversion towards PCV2 and Lawsonia intracellularis had a significant impact on PMWS in the Danish data, but it appears that the effect is positive, in the sense that seroconverted animals were less likely to develop PMWS. A number of maternal immunities also significantly affected PMWS development. Furthermore it was uncovered that most of these effects would not have been detected if pathogens were considered by themselves and not simultaneously.
Original languageEnglish
Title of host publicationBIT’s 5th World Congress of Vaccine
Number of pages1
Publication date2013
Publication statusPublished - 2013
EventBIT’s 5th World Congress of Vaccine - Hangzhou, China
Duration: 18 Mar 201320 Mar 2013
http://www.bitlifesciences.com/wcv2013/

Conference

ConferenceBIT’s 5th World Congress of Vaccine
CountryChina
CityHangzhou
Period18/03/201320/03/2013
Internet address

Cite this

Grau-Roma, L., Stockmarr, A., Kristensen, C. S., Enøe, C., López-Soria, S., Nofrarías, M., ... Larsen, L. E. (2013). PMWS Development in Pigs from Affected Farms in Spain and Denmark. In BIT’s 5th World Congress of Vaccine
Grau-Roma, L. ; Stockmarr, Anders ; Kristensen, C. S. ; Enøe, Claes ; López-Soria, S. ; Nofrarías, M. ; Bille-Hansen, Vivi ; Hjulsager, Charlotte Kristiane ; Sibila, M. ; Jorsal, Sven Erik Lind ; Fraile, L. ; Baekbo, P. ; Vigre, H. ; Segalés, J. ; Larsen, Lars Erik. / PMWS Development in Pigs from Affected Farms in Spain and Denmark. BIT’s 5th World Congress of Vaccine. 2013.
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title = "PMWS Development in Pigs from Affected Farms in Spain and Denmark",
abstract = "Postweaning multisystemic wasting syndrome (PMWS) is a worldwide spread condition that affects pigs in nursery and/or fattening units, and is considered to have a severe economic impact on swine production. The main clinical sign of PMWS is wasting, but can also include pallor of the skin, icterus, respiratory distress and diarrhoea. The main essential infectious agent for PMWS development is porcinecircovirus type 2 (PCV2), but the exact cause of PMWS is still unclear.PCV2 is present in most pig herds, but the occurrence of PMWS is more sporadic, and it is been difficult to reproduce PMWS by inoculating PCV2 alone. However, studies where co-infections have been applied have been more successful. Based on this, we modeled PMWS development based on longitudinal data on antibodies and PMWS status from herds in Denmark and Spain, where presence of a range of pathogens were considered as explanatory variables in the form of maternal immunity and the occurrence of seroconversion against the considered pathogens. However, maternal immunity could not be measured from mother animals due to cross fostering, no time points for seroconversion was available, and no case/control status could be assigned as PMWS do not have an ‘infectious period’ after which animals may be assigned control status. The talk will concentrate on the framework in which this was handled, which may be translated to similar settings for similar studies. We found that seroconversion towards PCV2 and Lawsonia intracellularis had a significant impact on PMWS in the Danish data, but it appears that the effect is positive, in the sense that seroconverted animals were less likely to develop PMWS. A number of maternal immunities also significantly affected PMWS development. Furthermore it was uncovered that most of these effects would not have been detected if pathogens were considered by themselves and not simultaneously.",
author = "L. Grau-Roma and Anders Stockmarr and Kristensen, {C. S.} and Claes En{\o}e and S. L{\'o}pez-Soria and M. Nofrar{\'i}as and Vivi Bille-Hansen and Hjulsager, {Charlotte Kristiane} and M. Sibila and Jorsal, {Sven Erik Lind} and L. Fraile and P. Baekbo and H. Vigre and J. Segal{\'e}s and Larsen, {Lars Erik}",
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Grau-Roma, L, Stockmarr, A, Kristensen, CS, Enøe, C, López-Soria, S, Nofrarías, M, Bille-Hansen, V, Hjulsager, CK, Sibila, M, Jorsal, SEL, Fraile, L, Baekbo, P, Vigre, H, Segalés, J & Larsen, LE 2013, PMWS Development in Pigs from Affected Farms in Spain and Denmark. in BIT’s 5th World Congress of Vaccine. BIT’s 5th World Congress of Vaccine, Hangzhou, China, 18/03/2013.

PMWS Development in Pigs from Affected Farms in Spain and Denmark. / Grau-Roma, L.; Stockmarr, Anders; Kristensen, C. S.; Enøe, Claes; López-Soria, S.; Nofrarías, M.; Bille-Hansen, Vivi; Hjulsager, Charlotte Kristiane; Sibila, M.; Jorsal, Sven Erik Lind; Fraile, L.; Baekbo, P.; Vigre, H.; Segalés, J.; Larsen, Lars Erik.

BIT’s 5th World Congress of Vaccine. 2013.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

TY - ABST

T1 - PMWS Development in Pigs from Affected Farms in Spain and Denmark

AU - Grau-Roma, L.

AU - Stockmarr, Anders

AU - Kristensen, C. S.

AU - Enøe, Claes

AU - López-Soria, S.

AU - Nofrarías, M.

AU - Bille-Hansen, Vivi

AU - Hjulsager, Charlotte Kristiane

AU - Sibila, M.

AU - Jorsal, Sven Erik Lind

AU - Fraile, L.

AU - Baekbo, P.

AU - Vigre, H.

AU - Segalés, J.

AU - Larsen, Lars Erik

PY - 2013

Y1 - 2013

N2 - Postweaning multisystemic wasting syndrome (PMWS) is a worldwide spread condition that affects pigs in nursery and/or fattening units, and is considered to have a severe economic impact on swine production. The main clinical sign of PMWS is wasting, but can also include pallor of the skin, icterus, respiratory distress and diarrhoea. The main essential infectious agent for PMWS development is porcinecircovirus type 2 (PCV2), but the exact cause of PMWS is still unclear.PCV2 is present in most pig herds, but the occurrence of PMWS is more sporadic, and it is been difficult to reproduce PMWS by inoculating PCV2 alone. However, studies where co-infections have been applied have been more successful. Based on this, we modeled PMWS development based on longitudinal data on antibodies and PMWS status from herds in Denmark and Spain, where presence of a range of pathogens were considered as explanatory variables in the form of maternal immunity and the occurrence of seroconversion against the considered pathogens. However, maternal immunity could not be measured from mother animals due to cross fostering, no time points for seroconversion was available, and no case/control status could be assigned as PMWS do not have an ‘infectious period’ after which animals may be assigned control status. The talk will concentrate on the framework in which this was handled, which may be translated to similar settings for similar studies. We found that seroconversion towards PCV2 and Lawsonia intracellularis had a significant impact on PMWS in the Danish data, but it appears that the effect is positive, in the sense that seroconverted animals were less likely to develop PMWS. A number of maternal immunities also significantly affected PMWS development. Furthermore it was uncovered that most of these effects would not have been detected if pathogens were considered by themselves and not simultaneously.

AB - Postweaning multisystemic wasting syndrome (PMWS) is a worldwide spread condition that affects pigs in nursery and/or fattening units, and is considered to have a severe economic impact on swine production. The main clinical sign of PMWS is wasting, but can also include pallor of the skin, icterus, respiratory distress and diarrhoea. The main essential infectious agent for PMWS development is porcinecircovirus type 2 (PCV2), but the exact cause of PMWS is still unclear.PCV2 is present in most pig herds, but the occurrence of PMWS is more sporadic, and it is been difficult to reproduce PMWS by inoculating PCV2 alone. However, studies where co-infections have been applied have been more successful. Based on this, we modeled PMWS development based on longitudinal data on antibodies and PMWS status from herds in Denmark and Spain, where presence of a range of pathogens were considered as explanatory variables in the form of maternal immunity and the occurrence of seroconversion against the considered pathogens. However, maternal immunity could not be measured from mother animals due to cross fostering, no time points for seroconversion was available, and no case/control status could be assigned as PMWS do not have an ‘infectious period’ after which animals may be assigned control status. The talk will concentrate on the framework in which this was handled, which may be translated to similar settings for similar studies. We found that seroconversion towards PCV2 and Lawsonia intracellularis had a significant impact on PMWS in the Danish data, but it appears that the effect is positive, in the sense that seroconverted animals were less likely to develop PMWS. A number of maternal immunities also significantly affected PMWS development. Furthermore it was uncovered that most of these effects would not have been detected if pathogens were considered by themselves and not simultaneously.

M3 - Conference abstract in proceedings

BT - BIT’s 5th World Congress of Vaccine

ER -

Grau-Roma L, Stockmarr A, Kristensen CS, Enøe C, López-Soria S, Nofrarías M et al. PMWS Development in Pigs from Affected Farms in Spain and Denmark. In BIT’s 5th World Congress of Vaccine. 2013