Plasma Phospholipid Long-Chain n-3 Polyunsaturated Fatty Acids and Body Weight Change

Marianne Uhre Jakobsen, Claus Dethlefsen, Karen M. Due, Nadia Slimani, Veronique Chajes, Anne M. May, Thorkild I. A. Sorensen, Jytte Halkjaer, Anne Tjonneland, Francoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Madlen Schuetze, Antonia Trichopoulou, Dimosthenis Zylis, George Makrygiannis, Domenico PalliAmalia Mattiello, Giovanna Tagliabue, Daphne L. van der A, H. B. Bueno-de-Mesquita, Laudina Rodriguez, Noemie Travier, Esther Molina-Montes, Jose M. Huerta, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfalt, Ingegerd Johansson, Goran Hallmans, Kay-Tee Khaw, Nicholas J. Wareham, Francesca Crowe, Isabelle Romieu, Elio Riboli, Petra H. M. Peeters, Kim Overvad

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Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.
Original languageEnglish
JournalObesity Facts
Issue number4
Pages (from-to)312-318
Number of pages7
Publication statusPublished - 2011
Externally publishedYes


  • Body weight
  • Cohort study
  • n-3 fatty acids
  • Omega-3 fatty acids
  • Weight change


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