Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition

Mitra Saadatian-Elahi, Nadia Slimani, Veronique Chajes, Mazda Jenab, Joelle Goudable, Carine Biessy, Pietro Ferrari, Graham Byrnes, Philippe Autier, Petra H. M. Peeters, Marga Ocke, Bas Bueno de Mesquita, Ingegerd Johansson, Goeran Hallmans, Jonas Manjer, Elisabet Wirfalt, Carlos A. Gonzalez, Carmen Navarro, Carmen Martinez, Pilar AmianoLaudina Rodriguez Suaerz, Eva Ardanaz, Anne Tjonneland, Jytte Halkjaer, Kim Overvad, Marianne Uhre Jakobsen, Franco Berrino, Valeria Pala, Domenico Palli, Rosario Tumino, Paolo Vineis, Maria Santucci de Magistris, Elisabeth A. Spencer, Francesca L. Crowe, Sheila Bingham, Kay-Tee Khaw, Jakob Linseisen, Sabine Rohrmann, Heiner Boeing, Ute Noethlings, Karina Standahl Olsen, Guri Skeie, Eiliv Lund, Antonia Trichopoulou, Erifili Oustoglou, Francoise Clavel-Chapelon, Elio Riboli

Research output: Contribution to journalJournal articlepeer-review

Abstract

Background: Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns. Objective: The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicenter study. Design: A cross-sectional study design nested to the European Prospective Investigation into Cancer and Nutrition (EPIC) was conducted to determine plasma fatty acid profiles in > 3000 subjects from 16 centers, who had also completed 24-h dietary recalls and dietary questionnaires. Plasma fatty acids were assessed by capillary gas chromatography. Ecological and individual correlations were calculated between fatty acids and select food groups. Results: The most important determinant of plasma fatty acids was region, which suggests that the variations across regions are largely due to different food intakes. Strong ecological correlations were observed between fish intake and long-chain n-3 polyunsaturated fatty acids (r = 0.78, P <0.01), olive oil and oleic acid (r = 0.73, P <0.01), and margarine and elaidic acid (r = 0.76, P <0.01). Individual correlations varied across the regions, particularly between olive oil and oleic acid and between alcohol and the saturation index, as an indicator of stearoyl CoA desaturase activity. Conclusions: These findings indicate that specific plasma phospholipid fatty acids are suitable biomarkers of some food intakes in the EPIC Study. Moreover, these findings suggest complex interactions between alcohol intake and fatty acid metabolism, which warrants further attention in epidemiologic studies relating dietary fatty acids to alcohol-related cancers and other chronic diseases.
Original languageEnglish
JournalAMERICAN JOURNAL OF CLINICAL NUTRITION
Volume89
Issue number1
Pages (from-to)331-346
Number of pages16
ISSN0002-9165
DOIs
Publication statusPublished - 2009
Externally publishedYes

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