Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

Veronique Chajes; Carine Biessy; Pietro Ferrari; Isabelle Romieu; Heinz Freisling; Inge Huybrechts; Augustin Scalbert; Bas Bueno de Mesquita; Dora Romaguera; Marc J. Gunter; Paolo Vineis; Camilla Plambeck Hansen; Marianne Uhre Jakobsen; Francoise Clavel-Chapelon; Guy Fagherazzi; Marie-Christine Boutron-Ruault; Verana Katzke; Jasmine Neamat-Allah; Heiner Boeing; Ursula Bachlechner; Antonia Trichopoulou; Androniki Naska; Philippos Orfanos; Valeria Pala; Giovanna Masala; Amalia Mattiello; Guri Skeie; Elisabete Weiderpass; Antonio Agudo; Jose Maria Huerta; Eva Ardanaz; Maria Jose Sanchez; Miren Dorronsoro; Jose Ramon Quiros; Ingegerd Johansson; Anna Winkvist; Emily Sonested; Tim Key; Kay-Tee Khaw; Nicolas J. Wareham; Petra H. M. Peeters; Nadia Slimani

doi:10.1371/journal.pone.0118206

Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

Veronique Chajes
, Carine Biessy
, Pietro Ferrari
, Isabelle Romieu
, Heinz Freisling
, Inge Huybrechts
, Augustin Scalbert
, Bas Bueno de Mesquita
, Dora Romaguera
, Marc J. Gunter
, Paolo Vineis
, Camilla Plambeck Hansen
, Marianne Uhre Jakobsen
, Francoise Clavel-Chapelon
, Guy Fagherazzi
, Marie-Christine Boutron-Ruault
, Verana Katzke
, Jasmine Neamat-Allah
, Heiner Boeing
, Ursula Bachlechner

Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Valeria Pala, Giovanna Masala, Amalia Mattiello, Guri Skeie, Elisabete Weiderpass, Antonio Agudo, Jose Maria Huerta, Eva Ardanaz, Maria Jose Sanchez, Miren Dorronsoro, Jose Ramon Quiros, Ingegerd Johansson, Anna Winkvist, Emily Sonested, Tim Key, Kay-Tee Khaw, Nicolas J. Wareham, Petra H. M. Peeters, Nadia Slimani

International Agency for Research on Cancer
Imperial College London
Aarhus University
Centre for Research in Epidemiology and Population Health
German Cancer Research Center
German Institute of Human Nutrition Potsdam-Rehbruecke
Hellenic Health Foundation
National Cancer Institute Italy
Cancer Research and Prevention Institute
University of Naples Federico II
University of Tromsø – The Arctic University of Norway
Catalan Institute of Oncology
Murcia Regional Health Council
CIBER Epidemiology and Public Health
Department of Health Basque Country
Ministry of Health, Consumption and Social Welfare
Umeå University
University of Gothenburg
Lund University
University of Oxford
University of Cambridge
Addenbrooke's Hospital

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Abstract

Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region.ResultsIn women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend

Original language	English
Article number	e0118206
Journal	P L o S One
Volume	10
Issue number	2
Number of pages	11
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0118206
Publication status	Published - 2015
Externally published	Yes

Bibliographical note

Copyright: © 2015 Chajès et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Chajes, V., Biessy, C., Ferrari, P., Romieu, I., Freisling, H., Huybrechts, I., Scalbert, A., de Mesquita, B. B., Romaguera, D., Gunter, M. J., Vineis, P., Hansen, C. P., Jakobsen, M. U., Clavel-Chapelon, F., Fagherazzi, G., Boutron-Ruault, M.-C., Katzke, V., Neamat-Allah, J., Boeing, H., ... Slimani, N. (2015). Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study. P L o S One, 10(2), Article e0118206. https://doi.org/10.1371/journal.pone.0118206

@article{be56465559244f978d5d48673ad80bcd,

title = "Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study",

abstract = "Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region.ResultsIn women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95\% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95\% CI = 0.97- 1.56, p = 0.082) ( p- trend",

author = "Veronique Chajes and Carine Biessy and Pietro Ferrari and Isabelle Romieu and Heinz Freisling and Inge Huybrechts and Augustin Scalbert and \{de Mesquita\}, \{Bas Bueno\} and Dora Romaguera and Gunter, \{Marc J.\} and Paolo Vineis and Hansen, \{Camilla Plambeck\} and Jakobsen, \{Marianne Uhre\} and Francoise Clavel-Chapelon and Guy Fagherazzi and Marie-Christine Boutron-Ruault and Verana Katzke and Jasmine Neamat-Allah and Heiner Boeing and Ursula Bachlechner and Antonia Trichopoulou and Androniki Naska and Philippos Orfanos and Valeria Pala and Giovanna Masala and Amalia Mattiello and Guri Skeie and Elisabete Weiderpass and Antonio Agudo and \{Maria Huerta\}, Jose and Eva Ardanaz and \{Jose Sanchez\}, Maria and Miren Dorronsoro and \{Ramon Quiros\}, Jose and Ingegerd Johansson and Anna Winkvist and Emily Sonested and Tim Key and Kay-Tee Khaw and Wareham, \{Nicolas J.\} and Peeters, \{Petra H. M.\} and Nadia Slimani",

note = "Copyright: {\textcopyright} 2015 Chaj{\`e}s et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2015",

doi = "10.1371/journal.pone.0118206",

language = "English",

volume = "10",

journal = "P L o S One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "2",

}

Chajes, V, Biessy, C, Ferrari, P, Romieu, I, Freisling, H, Huybrechts, I, Scalbert, A, de Mesquita, BB, Romaguera, D, Gunter, MJ, Vineis, P, Hansen, CP, Jakobsen, MU, Clavel-Chapelon, F, Fagherazzi, G, Boutron-Ruault, M-C, Katzke, V, Neamat-Allah, J, Boeing, H, Bachlechner, U, Trichopoulou, A, Naska, A, Orfanos, P, Pala, V, Masala, G, Mattiello, A, Skeie, G, Weiderpass, E, Agudo, A, Maria Huerta, J, Ardanaz, E, Jose Sanchez, M, Dorronsoro, M, Ramon Quiros, J, Johansson, I, Winkvist, A, Sonested, E, Key, T, Khaw, K-T, Wareham, NJ, Peeters, PHM & Slimani, N 2015, 'Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study', P L o S One, vol. 10, no. 2, e0118206. https://doi.org/10.1371/journal.pone.0118206

TY - JOUR

T1 - Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change

T2 - Report from the EPIC Study

AU - Chajes, Veronique

AU - Biessy, Carine

AU - Ferrari, Pietro

AU - Romieu, Isabelle

AU - Freisling, Heinz

AU - Huybrechts, Inge

AU - Scalbert, Augustin

AU - de Mesquita, Bas Bueno

AU - Romaguera, Dora

AU - Gunter, Marc J.

AU - Vineis, Paolo

AU - Hansen, Camilla Plambeck

AU - Jakobsen, Marianne Uhre

AU - Clavel-Chapelon, Francoise

AU - Fagherazzi, Guy

AU - Boutron-Ruault, Marie-Christine

AU - Katzke, Verana

AU - Neamat-Allah, Jasmine

AU - Boeing, Heiner

AU - Bachlechner, Ursula

AU - Trichopoulou, Antonia

AU - Naska, Androniki

AU - Orfanos, Philippos

AU - Pala, Valeria

AU - Masala, Giovanna

AU - Mattiello, Amalia

AU - Skeie, Guri

AU - Weiderpass, Elisabete

AU - Agudo, Antonio

AU - Maria Huerta, Jose

AU - Ardanaz, Eva

AU - Jose Sanchez, Maria

AU - Dorronsoro, Miren

AU - Ramon Quiros, Jose

AU - Johansson, Ingegerd

AU - Winkvist, Anna

AU - Sonested, Emily

AU - Key, Tim

AU - Khaw, Kay-Tee

AU - Wareham, Nicolas J.

AU - Peeters, Petra H. M.

AU - Slimani, Nadia

N1 - Copyright: © 2015 Chajès et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2015

Y1 - 2015

N2 - Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region.ResultsIn women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend

AB - Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region.ResultsIn women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend

U2 - 10.1371/journal.pone.0118206

DO - 10.1371/journal.pone.0118206

M3 - Journal article

SN - 1932-6203

VL - 10

JO - P L o S One

JF - P L o S One

IS - 2

M1 - e0118206

ER -

Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

Abstract

Bibliographical note

UN SDGs

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