Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

Veronique Chajes, Carine Biessy, Pietro Ferrari, Isabelle Romieu, Heinz Freisling, Inge Huybrechts, Augustin Scalbert, Bas Bueno de Mesquita, Dora Romaguera, Marc J. Gunter, Paolo Vineis, Camilla Plambeck Hansen, Marianne Uhre Jakobsen, Francoise Clavel-Chapelon, Guy Fagherazzi, Marie-Christine Boutron-Ruault, Verana Katzke, Jasmine Neamat-Allah, Heiner Boeing, Ursula BachlechnerAntonia Trichopoulou, Androniki Naska, Philippos Orfanos, Valeria Pala, Giovanna Masala, Amalia Mattiello, Guri Skeie, Elisabete Weiderpass, Antonio Agudo, Jose Maria Huerta, Eva Ardanaz, Maria Jose Sanchez, Miren Dorronsoro, Jose Ramon Quiros, Ingegerd Johansson, Anna Winkvist, Emily Sonested, Tim Key, Kay-Tee Khaw, Nicolas J. Wareham, Petra H. M. Peeters, Nadia Slimani

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Abstract

Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region.ResultsIn women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend
Original languageEnglish
Article numbere0118206
JournalP L o S One
Volume10
Issue number2
Number of pages11
ISSN1932-6203
DOIs
Publication statusPublished - 2015
Externally publishedYes

Bibliographical note

Copyright: © 2015 Chajès et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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