TY - JOUR
T1 - Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change
T2 - Report from the EPIC Study
AU - Chajes, Veronique
AU - Biessy, Carine
AU - Ferrari, Pietro
AU - Romieu, Isabelle
AU - Freisling, Heinz
AU - Huybrechts, Inge
AU - Scalbert, Augustin
AU - de Mesquita, Bas Bueno
AU - Romaguera, Dora
AU - Gunter, Marc J.
AU - Vineis, Paolo
AU - Hansen, Camilla Plambeck
AU - Jakobsen, Marianne Uhre
AU - Clavel-Chapelon, Francoise
AU - Fagherazzi, Guy
AU - Boutron-Ruault, Marie-Christine
AU - Katzke, Verana
AU - Neamat-Allah, Jasmine
AU - Boeing, Heiner
AU - Bachlechner, Ursula
AU - Trichopoulou, Antonia
AU - Naska, Androniki
AU - Orfanos, Philippos
AU - Pala, Valeria
AU - Masala, Giovanna
AU - Mattiello, Amalia
AU - Skeie, Guri
AU - Weiderpass, Elisabete
AU - Agudo, Antonio
AU - Maria Huerta, Jose
AU - Ardanaz, Eva
AU - Jose Sanchez, Maria
AU - Dorronsoro, Miren
AU - Ramon Quiros, Jose
AU - Johansson, Ingegerd
AU - Winkvist, Anna
AU - Sonested, Emily
AU - Key, Tim
AU - Khaw, Kay-Tee
AU - Wareham, Nicolas J.
AU - Peeters, Petra H. M.
AU - Slimani, Nadia
N1 - Copyright: © 2015 Chajès et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2015
Y1 - 2015
N2 - Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region.ResultsIn women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend
AB - Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region.ResultsIn women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend
U2 - 10.1371/journal.pone.0118206
DO - 10.1371/journal.pone.0118206
M3 - Journal article
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e0118206
ER -
