Abstract
PINTA (available at http://www.esat.kuleuven.be/
pinta/; this web site is free and open to all users
and there is no login requirement) is a web
resource for the prioritization of candidate genes
based on the differential expression of their neighborhood
in a genome-wide protein–protein interaction
network. Our strategy is meant for
biological and medical researchers aiming at identifying
novel disease genes using disease specific
expression data. PINTA supports both candidate
gene prioritization (starting from a user defined set
of candidate genes) as well as genome-wide gene
prioritization and is available for five species
(human, mouse, rat, worm and yeast). As input
data, PINTA only requires disease specific expression
data, whereas various platforms (e.g.
Affymetrix) are supported. As a result, PINTA
computes a gene ranking and presents the results
as a table that can easily be browsed and downloaded
by the user.
Original language | English |
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Journal | Nucleic Acids Research |
Volume | 39 |
Issue number | Suppl. 2 |
Pages (from-to) | W334-W338 |
ISSN | 0305-1048 |
DOIs | |
Publication status | Published - 2011 |