Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions

Jesper Bo Damm Jensen, Lars H. Pedersen, Poul E. Hoiby, Lars B. Nielsen, Theis Peter Hansen, Jacob Riis Folkenberg, Jesper Riishede, Danny Noordegraaf, Kristian Nielsen, Anneline Carlsen, Anders Overgaard Bjarklev

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Abstract

We demonstrate highly efficient evanescent-wave detection of fluorophore-labeled biomolecules in aqueous solutions positioned in the air holes of the microstructured part of a photonic crystal fiber. The air-suspended silica structures located between three neighboring air holes in the cladding crystal guide light with a large fraction of the optical field penetrating into the sample even at wavelengths in the visible range. An effective interaction length of several centimeters is obtained when a sample volume of less than 1 µL is used.
Original languageEnglish
JournalOptics Letters
Volume29
Issue number17
Pages (from-to)1974-1976
ISSN1094-4087
DOIs
Publication statusPublished - 2004

Cite this

Jensen, J. B. D., Pedersen, L. H., Hoiby, P. E., Nielsen, L. B., Hansen, T. P., Folkenberg, J. R., Riishede, J., Noordegraaf, D., Nielsen, K., Carlsen, A., & Bjarklev, A. O. (2004). Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions. Optics Letters, 29(17), 1974-1976. https://doi.org/10.1364/OL.29.001974