Photolabile Linkers for Solid-Phase Synthesis

Remi J. T. Mikkelsen, Katja E. Grier, Kim T. Mortensen, Thomas . Nielsen, Katrine Qvortrup*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Photolabile linkers are the subjects of intense research, because they allow the release of the target molecule simply by irradiation. Photochemical substrate release is often facilitated without additional reagents under mild reaction conditions, which may even be environmentally friendly and appealing in the context of greener chemistry. The mild conditions may, furthermore, become attractive for applications of released crude material in subsequent biological screening experiments, where contamination with cleavage reagents would be detrimental. This review pays attention to the increasing number of photolabile linkers developed for solid-phase synthesis and release. It covers (i) o-nitrobenzyloxy linkers, (ii) o-nitrobenzylamino linkers, (iii) α-substituted o-nitrobenzyl linkers, (iv) o-nitroveratryl linkers, (v) phenacyl linkers, (vi) p-alkoxyphenacyl linkers, (vii) benzoin linkers, (viii) pivaloyl linkers, (ix) other photolabile linkers.
Original languageEnglish
JournalA C S Combinatorial Science
Issue number7
Pages (from-to)377-399
Publication statusPublished - 2018


  • Solid-phase synthesis
  • Photolabile linker
  • Combinatorial chemistry
  • Chemical biology.

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