Photolabile linker for the synthesis of hydroxamic acids

Thomas Eiland Nielsen (Inventor), Katrine Qvortrup (Inventor)

Research output: Patent

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The present invention relates to a photolabile hydroxamate linker based on the o - nitroveratryl group and its application for multistep solid-phase synthesis and controlled photolytic release of hydroxamic acids. The invention provides a method for producing a solid support comprising a hydroxylamine - functionalized photolabile linker, and the so produced hydroxylamine - functionalized photolabile solid support. The invention further provides a method for synthesizing a one-bead-one compound library of hydroxamic acid derivatives on a photolabile linker, as well as a method for screening a library of hydroxamic acid derivatives.
Original languageEnglish
IPCC07C235/06; C07C237/22; C07C237/42
Patent numberWO2013057186
Filing date18/10/2012
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Publication statusPublished - 2013

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