Photoinduced transition-metal-catalyzed enantioselective functionalization of non-acidic C(sp³)−H bonds

Enantioselective C(sp³)−H functionalization is a highly efficient strategy for the introduction of new stereocenters and the synthesis of enantioenriched chiral compounds. Recent developments in the field of photoinduced transition-metal catalysis have led to impressive advances toward this goal. New methods involving photocatalyzed conversion of C(sp³)−H bonds into radical intermediates that are directly trapped by chiral transition-metal catalysts have proven particularly powerful. This perspective provides an overview of these methods for the direct transformation of non-acidic C(sp³)−H bonds into carbon–carbon or carbon–heteroatom bonds in an enantioselective fashion. We conclude with an outlook on challenges and future opportunities.