Abstract
Enantioselective C(sp3)−H functionalization is a highly efficient strategy for the introduction of new stereocenters and the synthesis of enantioenriched chiral compounds. Recent developments in the field of photoinduced transition-metal catalysis have led to impressive advances toward this goal. New methods involving photocatalyzed conversion of C(sp3)−H bonds into radical intermediates that are directly trapped by chiral transition-metal catalysts have proven particularly powerful. This perspective provides an overview of these methods for the direct transformation of non-acidic C(sp3)−H bonds into carbon–carbon or carbon–heteroatom bonds in an enantioselective fashion. We conclude with an outlook on challenges and future opportunities.
Original language | English |
---|---|
Article number | 100854 |
Journal | Chem Catalysis |
Volume | 4 |
Issue number | 1 |
Number of pages | 13 |
ISSN | 2667-1107 |
DOIs | |
Publication status | Published - 2024 |