Photoinduced transition-metal-catalyzed enantioselective functionalization of non-acidic C(sp3)−H bonds

Xuemeng Chen, Søren Kramer*

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

Abstract

Enantioselective C(sp3)−H functionalization is a highly efficient strategy for the introduction of new stereocenters and the synthesis of enantioenriched chiral compounds. Recent developments in the field of photoinduced transition-metal catalysis have led to impressive advances toward this goal. New methods involving photocatalyzed conversion of C(sp3)−H bonds into radical intermediates that are directly trapped by chiral transition-metal catalysts have proven particularly powerful. This perspective provides an overview of these methods for the direct transformation of non-acidic C(sp3)−H bonds into carbon–carbon or carbon–heteroatom bonds in an enantioselective fashion. We conclude with an outlook on challenges and future opportunities.

Original languageEnglish
Article number100854
JournalChem Catalysis
Volume4
Issue number1
Number of pages13
ISSN2667-1107
DOIs
Publication statusPublished - 2024

Fingerprint

Dive into the research topics of 'Photoinduced transition-metal-catalyzed enantioselective functionalization of non-acidic C(sp3)−H bonds'. Together they form a unique fingerprint.

Cite this